Progressive decrease of left superior temporal gyrus gray matter volume in patients with first-episode schizophrenia
Progressive decrease of left superior temporal gyrus gray matter volume in patients with first-episode schizophrenia
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DOI：
10.1176/appi.ajp.160.1.156
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发表时间：
2003-01-01
影响因子：
17.7
通讯作者：
McCarley, RW
中科院分区：
文献类型：
--
作者：
Kasai, K;Shenton, ME;McCarley, RW
目的：在慢性精神分裂症患者的磁共振成像（MRI）研究中报告了较小的颞叶皮质灰质体积，包括左侧上级颞回，最近，在首发精神分裂症患者中也有报告。然而，尚不清楚首发精神分裂症患者的颞叶皮质灰质体积是否存在进行性减少，以及情感性精神病患者是否存在类似的进行性体积减少。方法：13名首发精神分裂症患者在首次住院时和1.5年后进行了高空间分辨率MRI扫描，15例首发情感性精神病（主要为躁狂）患者和14例健康对照者。MRI体积计算为灰质的上级颞回和杏仁核-海马complex.Results：首发精神分裂症患者表现出显着减少，随着时间的推移，在左侧上级颞回的灰质体积与首发情感性精神病患者或健康对照组相比。这种进行性降低在左侧上级颞回后部（平均值=9.6%）比前部（平均值=8.4%）更明显。随着时间的推移，没有组间差异的变化率存在于其他regions.Conclusions：这些研究结果表明，左后上级颞回灰质的首发精神分裂症患者，但不是在首发情感性精神病患者的体积进行性减少。
Objective: Smaller temporal lobe cortical gray matter volumes, including the left superior temporal gyrus, have been reported in magnetic resonance imaging (MRI) studies of patients with chronic schizophrenia and, more recently, in patients with first-episode schizophrenia. However, it remains unknown whether there are progressive decreases in temporal lobe cortical gray matter volumes in patients with first-episode schizophrenia and whether similarly progressive volume decreases are present in patients with affective psychosis.Method: High-spatial-resolution MRI scans at initial hospitalization and 1.5 years later were obtained from 13 patients with first-episode schizophrenia, 15 patients with first-episode affective psychosis (mainly manic), and 14 healthy comparison subjects. MRI volumes were calculated for gray matter of superior temporal gyrus and for the amygdala-hippocampal complex.Results: Patients with first-episode schizophrenia showed significant decreases in gray matter volume over time in the left superior temporal gyrus compared with patients with first-episode affective psychosis or healthy comparison subjects. This progressive decrease was more pronounced in the posterior portion of the left superior temporal gyrus (mean=9.6%) than in the anterior portions (mean=8.4%). No group differences in the rate of change over time were present in other regions.Conclusions: These findings demonstrate a progressive volume reduction of the left posterior superior temporal gyrus gray matter in patients with first-episode schizophrenia but not in patients with first-episode affective psychosis.