Collagenase in cranial morphogenesis
Collagenase in cranial morphogenesis
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DOI：
10.1159/000091377
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发表时间：
2005-01-01
影响因子：
2.7
通讯作者：
Holmbeck, K
中科院分区：
文献类型：
--
作者：
Holmbeck, K
胶原蛋白是高等动物结缔组织中最丰富的细胞外基质蛋白。结缔组织的生长与在发育和生长过程中的关键点建模和重塑生物体富含胶原蛋白基质的能力密切相关，以允许组织界面的扩张和适应。哺乳动物的颅骨是胶原蛋白重塑需要其正常生长的地方之一，这篇综述探讨了胶原蛋白重塑被废除的后果，因为它们在缺乏膜 1 型基质金属蛋白酶的小鼠模型中实现。版权所有 (c) 2005 S. Karger AG，巴塞尔。
Collagen is the most abundant extracellular matrix protein in connective tissues of higher animals. The growth of connective tissues is intimately linked to the ability to model and remodel the collagen-rich matrices of the organism at critical points during development and growth to allow expansion and adaptation of tissue interfaces. The mammalian cranium is one such place where collagen remodeling is required for proper growth, and this review explores the consequences of abrogated collagen remodeling as they materialize in a mouse model deficient for the membrane type 1 matrix metalloproteinase. Copyright (c) 2005 S. Karger AG, Basel.