Rapid dopamine dynamics in the accumbens core and shell: learning and action.
Rapid dopamine dynamics in the accumbens core and shell: learning and action.
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DOI：
10.2741/e615
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发表时间：
2013-01-01
期刊：
影响因子：
--
通讯作者：
Carelli RM
中科院分区：
文献类型：
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作者：
Saddoris MP;Sugam JA;Cacciapaglia F;Carelli RM
儿茶酚胺多巴胺 (DA) 与精神分裂症、帕金森症和奖赏编码等多种神经过程有关。重要的是，DA 功能的这些独特特征在很大程度上归因于独立的神经回路，涉及来自不同 DA 释放核的连接以及对独立传入目标的投射。新出现的数据表明，独立神经回路的相同原理可能适用于结构分区，例如伏隔核（NAc）的核心和外壳。此外，DA 可以通过不同的 DA 受体密度和微电路的不同输入和输出选择性地作用于较小的细胞群（或微电路），从而能够对巴甫洛夫线索、仪器反应、主观奖励处理和决策进行新的了解。在这篇综述中，通过利用亚秒伏安技术对行为动物进行研究，研究 DA 水平的快速变化如何影响行为，我们研究了 DA 释放的空间和时间特征，以及它与正常学习和成瘾形式的病理学习的相似性。
The catecholamine dopamine (DA) has been implicated in a host of neural processes as diverse as schizophrenia, parkinsonism and reward encoding. Importantly, these distinct features of DA function are due in large part to separate neural circuits involving connections arising from different DA-releasing nuclei and projections to separate afferent targets. Emerging data has suggested that this same principle of separate neural circuits may be applicable within structural subregions, such as the core and shell of the nucleus accumbens (NAc). Further, DA may act selectively on smaller ensembles of cells (or, microcircuits) via differential DA receptor density and distinct inputs and outputs of the microcircuits, thus enabling new learning about Pavlovian cues, instrumental responses, subjective reward processing and decision-making. In this review, by taking advantage of studies using subsecond voltammetric techniques in behaving animals to study how rapid changes in DA levels affect behavior, we examine the spatial and temporal features of DA release and how it relates to both normal learning and similarities to pathological learning in the form of addiction.