Prenatal and childhood antecedents of suicide: 50-year follow-up of the 1958 British Birth Cohort Study
Prenatal and childhood antecedents of suicide: 50-year follow-up of the 1958 British Birth Cohort Study
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DOI：
10.1017/s003329171300189x
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发表时间：
2014-04-01
影响因子：
6.9
通讯作者：
Power, C.
中科院分区：
文献类型：
--
作者：
Geoffroy, M-C;Gunnell, D.;Power, C.
背景我们的目的是阐明自杀的早期前因，包括儿童早期发育的可能中介。使用1958年出生队列，基于1958年3月英国出生，个体被随访至成年。我们使用的数据收集在出生时，并在7岁的各种线人。截至2009年5月31日发生的自杀事件是从相关的国家死亡证明中确定的。采用多变量考克斯比例风险模型分析其危险因素。共有12399名参与者（n=44例自杀者）有完整的数据。最强的产前自杀风险因素是：出生顺序，晚出生的孩子风险增加[p（趋势）=0.063，调整后的风险比（HR）]，e。G.对于第四胎或以后出生的孩子[HR=2.27，95%置信区间（CI）0.90-5.75];年轻母亲年龄（HR=1.18，95% CI 0.34-4.13，419岁; HR=0.41，95% CI 0.19-0.91，>29岁，p（趋势）=0.034）;和低（
Background. We aimed to elucidate early antecedents of suicide including possible mediation by early child development.Method. Using the 1958 birth cohort, based on British births in March 1958, individuals were followed up to adulthood. We used data collected at birth and at age 7 years from various informants. Suicides occurring up to 31 May 2009 were identified from linked national death certificates. Multivariable Cox proportional hazard models were used to investigate risk factors.Results. Altogether 12399 participants (n=44 suicides) had complete data. The strongest prenatal risk factors for suicide were: birth order, with risk increasing in later-born children [p(trend)=0.063, adjusted hazard ratio (HR)], e. g. for fourth-or later-born children [HR=2.27, 95% confidence interval (CI) 0.90-5.75]; young maternal age (HR=1.18, 95% CI 0.34-4.13 for 419 years and HR=0.41, 95% CI 0.19-0.91 for >29 years, p(trend)=0.034); and low (