Impact of the ESM-1 Gene Expression on Outcomes in Stage II/III Gastric Cancer Patients Who Received Adjuvant S-1 Chemotherapy
Impact of the ESM-1 Gene Expression on Outcomes in Stage II/III Gastric Cancer Patients Who Received Adjuvant S-1 Chemotherapy
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DOI：
10.21873/invivo.11796
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发表时间：
2020-01-01
期刊：
影响因子：
2.3
通讯作者：
Oshima, Takashi
中科院分区：
文献类型：
--
作者：
Kano, Kazuki;Sakamaki, Kentaro;Oshima, Takashi
背景/目的：内皮细胞特异性分子-1（ESM-1）是一种可溶性蛋白多糖，在多种生物学事件中发挥重要作用。我们研究了ESM-1在癌组织中的表达对接受辅助S-1化疗的11/111期胃癌患者预后的影响。方法：检测253例胃癌组织及癌旁正常粘膜中ESM-1 mRNA的表达。研究ESM-1基因表达与生存率和临床病理特征之间的关系。结果：ESM-1高表达与未分化腺癌的发生有显著相关性。ESM-1高表达患者的总生存曲线显著低于低表达患者（p=0.005）。高ESM-1表达是一个显著的独立预测因子（HR=2.291，p=0.007）。结论：ESM-1基因在癌组织中的表达是II/III期胃癌患者接受S-1辅助化疗的重要指标。
Background/Aim: Endothelial cell-specific molecule-1 (ESM-1) is a soluble proteoglycan which has important role in various biological events. We investigated the impact of the ESM-1 expression in cancer tissues on outcomes in stage 11/111 gastric cancer patients who received adjuvant S-1 chemotherapy. Patients and Methods: The ESM-1 mRNA expression in cancerous tissues and adjacent normal mucosa from 253 patients was measured. The associations between the ESM-1 gene expression and the survival and clinicopathological features were investigated. Results: A significant association was observed between high ESM-1 expression and undifferentiated adenocarcinoma. The overall survival curve was significantly lower in patients with high ESM-1 expression than in those with low expression (p=0.005). High ESM-1 expression was a significant independent prognosticator (HR=2.291, p=0.007). Conclusion: ESM-1 gene expression in cancerous tissues is an important prognosticator in stage II/III gastric cancer patients who received adjuvant S-1 chemotherapy.