Does ingested fat produce satiety?
Does ingested fat produce satiety?
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摄入的脂肪会产生饱腹感吗？
DOI：
10.1152/ajpregu.1996.270.4.r761
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Friedman,MI
中科院分区：
文献类型：
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作者：
Horn,CC;Tordoff,MG;Friedman,MI
将脂肪直接注入大鼠胃肠道，可迅速且通常显著减少进食行为。这与脂肪餐的正常消费形成对比，脂肪餐对随后的食物摄入量几乎没有影响。为了确定程序差异是否解释了这种差异，我们检查了摄入的脂肪对大鼠食物摄入的饱腹作用，所述大鼠保持在与涉及脂肪胃肠道递送的研究中所采用的那些类似的喂养条件下（即，食物剥夺、流质饮食）。摄入约1.5 ml玉米油对随后的流质饮食摄入量没有影响，直到摄入油后90 min。当大鼠在进入流质饮食前4小时摄入油时，为了留出额外的胃肠道清除时间，在进入的前30分钟内将流质饮食摄入量减少13%。这些发现表明，摄入的脂肪会略微降低短期摄入量，但只有在吸收后传递时间允许的情况下。这些结果质疑了直接将脂肪注入胃肠道后观察到的明显抑制食物摄入的生理意义。
Administration of fat directly into the gastrointestinal tract of rats produces a rapid and often substantial reduction of feeding behavior. This contrasts with the normal consumption of a fat meal, which produces little change in subsequent food intake. To determine whether procedural differences account for this discrepancy, we examined the satiating effect of ingested fat on food intake of rats maintained under feeding conditions similar to those employed in studies involving gastrointestinal delivery of fat (i.e., food deprivation, liquid diet). Ingestion of approximately 1.5 ml corn oil had no effect on subsequent liquid diet intake until 90 min after oil ingestion. When rats ingested oil 4 h before access to the liquid diet, to allow time for additional gastrointestinal clearance, liquid diet intake was reduced by 13% in the first 30 min of access. These findings indicate that ingested fat decreases short-term intake slightly, but only if time is allowed for postabsorptive delivery. The results question the physiological significance of the marked suppression of food intake observed in response to administration of fat directly into the gastrointestinal tract.