Gastrointestinal symptoms of 95 cases with SARS-CoV-2 infection
Gastrointestinal symptoms of 95 cases with SARS-CoV-2 infection
复制标题
95例SARS-CoV-2胃肠道症状
DOI：
10.1136/gutjnl-2020-321013
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发表时间：
2020-06-01
期刊：
影响因子：
24.5
通讯作者：
Shan, Hong
中科院分区：
文献类型：
--
作者：
Lin, Lu;Jiang, Xiayang;Shan, Hong
目的研究严重急性呼吸综合征（SARS）冠状病毒2型（SARS-CoV-2）感染患者的胃肠道症状。设计我们分析了2019年95例SARS冠状病毒2型感染患者的流行病学、人口学、临床和实验室数据。结果95例患者中，58例有胃肠道症状，11例（11.6%）在入院时出现，47例（49.5%）在住院期间出现。主要症状为腹泻（24.2%）、厌食（17.9%）和恶心（17.9%），发病时分别有5例（5.3%）、5例（5.3%）和3例（3.2%）。很大一部分患者在住院期间出现腹泻，可能因各种药物（包括抗生素）而加重。对65名住院患者的粪便样本进行了SARS-CoV-2检测，包括42名有胃肠道症状的患者和23名无胃肠道症状的患者，其中分别有22名（52.4%）和9名（39.1%）阳性。6例有胃肠道症状的患者接受了内镜检查，1例严重患者出现食管出血伴糜烂和溃疡。两例重症患者的食管、胃、十二指肠和直肠标本中均检测到SARS-CoV-2 RNA。结论胃肠道可能是SARS-CoV-2潜在的传播途径和靶器官。
Objective To study the GI symptoms in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected patients.Design We analysed epidemiological, demographic, clinical and laboratory data of 95 cases with SARS-CoV-2 caused coronavirus disease 2019. Real-time reverse transcriptase PCR was used to detect the presence of SARS-CoV-2 in faeces and GI tissues.Results Among the 95 patients, 58 cases exhibited GI symptoms of which 11 (11.6%) occurred on admission and 47 (49.5%) developed during hospitalisation. Diarrhoea (24.2%), anorexia (17.9%) and nausea (17.9%) were the main symptoms with five (5.3%), five (5.3%) and three (3.2%) cases occurred on the illness onset, respectively. A substantial proportion of patients developed diarrhoea during hospitalisation, potentially aggravated by various drugs including antibiotics. Faecal samples of 65 hospitalised patients were tested for the presence of SARS-CoV-2, including 42 with and 23 without GI symptoms, of which 22 (52.4%) and 9 (39.1%) were positive, respectively. Six patients with GI symptoms were subjected to endoscopy, revealing oesophageal bleeding with erosions and ulcers in one severe patient. SARS-CoV-2 RNA was detected in oesophagus, stomach, duodenum and rectum specimens for both two severe patients. In contrast, only duodenum was positive in one of the four non-severe patients.Conclusions GI tract may be a potential transmission route and target organ of SARS-CoV-2.