Improving Reproducibility in Synthetic Biology
Improving Reproducibility in Synthetic Biology
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DOI：
10.3389/fbioe.2019.00018
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发表时间：
2019-02-11
影响因子：
5.7
通讯作者：
Sonnenschein, Nikolaus
中科院分区：
文献类型：
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作者：
Jessop-Fabre, Mathew M.;Sonnenschein, Nikolaus
合成生物学在未来几年为世界提供变革性技术的前景广阔。然而，在它能够兑现其承诺之前，仍有若干挑战有待解决。需要解决的最重要问题之一是生命科学研究中缺乏可重复性。这个问题已开始被社会所认识，并正在制定解决方案来解决这个问题。最近出现的可供研究人员使用的自动化设施（如生物制造厂和云实验室）可能是合成生物学家提高工作质量和可重复性的方法之一。在这篇观点文章中，我们概述了这些技术以及目前正在开发的其他一些技术，我们认为这些技术可能有助于改变合成生物学家如何处理他们的研究活动。
Synthetic biology holds great promise to deliver transformative technologies to the world in the coming years. However, several challenges still remain to be addressed before it can deliver on its promises. One of the most important issues to address is the lack of reproducibility within research of the life sciences. This problem is beginning to be recognised by the community and solutions are being developed to tackle the problem. The recent emergence of automated facilities that are open for use by researchers (such as biofoundries and cloud labs) may be one of the ways that synthetic biologists can improve the quality and reproducibility of their work. In this perspective article, we outline these and some of the other technologies that are currently being developed which we believe may help to transform how synthetic biologists approach their research activities.