Logical analysis of the budding yeast cell cycle
Logical analysis of the budding yeast cell cycle
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DOI：
10.1016/j.jtbi.2008.12.028
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发表时间：
2009-04-21
影响因子：
2
通讯作者：
Irons, D. J.
中科院分区：
文献类型：
--
作者：
Irons, D. J.
芽殖酵母酿酒酵母是一种模型生物，通常用于研究真核细胞周期的控制。而且，由于野生型和突变体表型的大量实验数据，也特别适合数学、建模和分析。在这里，1 提出了芽殖酵母细胞周期的新布尔模型。该模型与多种野生型和突变体表型一致，并且在反应时间和组成基因/蛋白质的状态方面表现出显着的抗扰动能力。由于其简单的逻辑性质，该模型适合进行子网络分析，可用于识别细胞周期调节的四节点核心调节电路。子网络分析还可用于识别对可行的细胞周期控制至关重要的关键子动态，以及识别不同突变体之间变化最大的子动态。 (C) 2009 Elsevier Ltd. 保留所有权利。
The budding yeast Saccharomyces cerevisiae is a model organism that is commonly used to investigate control of the eukaryotic cell cycle. Moreover, because of the extensive experimental data on wild type and mutant phenotypes, it is also particularly suitable for mathematical,modelling and analysis. Here, 1 present a new Boolean model of the budding yeast cell cycle. This model is consistent with a wide range of wild type and mutant phenotypes and shows remarkable robustness against perturbations, both to reaction times and the states of component genes/proteins. Because of its simple logical nature, the model is suitable for sub-network analysis, which can be used to identify a four node core regulatory circuit underlying cell cycle regulation. Sub-network analysis can also be used to identify key sub-dynamics that are essential for viable cell cycle control, as well as identifying the sub-dynamics that are most variable between different mutants. (C) 2009 Elsevier Ltd. All rights reserved.