Ethnic and sex differences in circulating endotoxin levels: A novel marker of atherosclerotic and cardiovascular risk in a British multi-ethnic population
Ethnic and sex differences in circulating endotoxin levels: A novel marker of atherosclerotic and cardiovascular risk in a British multi-ethnic population
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DOI：
10.1016/j.atherosclerosis.2008.06.018
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发表时间：
2009-04-01
期刊：
影响因子：
5.3
通讯作者：
Cappuccio, Francesco P.
中科院分区：
文献类型：
--
作者：
Miller, Michelle A.;McTernan, Philip G.;Cappuccio, Francesco P.
背景：循环内毒素水平与动脉粥样硬化有关。此外，促炎标志物的种族差异可能与动脉粥样硬化和心血管（CVD）和冠心病（CHD）风险的种族差异相关。 目的和方法：探讨循环血浆内毒素水平、其可溶性受体（sCD14）和高敏CRP（hs-CRP）水平的种族差异。从英国“Wandsworth 心脏和中风研究”中随机选取 192 名年龄在 40-59 岁之间的个体（61 名白人（30 名女性）、68 名非洲裔（33 名女性）和 63 名南亚人（33 名女性）），无冠心病 (CHD)、中风、CVD 和糖尿病。结果：女性的年龄调整内毒素水平低于男性 (p=0.002)，并且在南方最高亚洲人 (13.3 EU/mL [95% CI 12.0-14.7]) 和非洲裔个体中最低 (10.1 EU/mL [9.1-11.1]) 比白人低（p 为线性趋势）
Background: Circulating endotoxin levels are associated with atherosclerosis. Moreover, ethnic differences in pro-inflammatory markers may be associated with ethnic differences in atherosclerotic and cardiovascular (CVD) and coronary heart disease (CHD) risk.Objective and methods: To investigate ethnic differences in circulating plasma endotoxin levels, its soluble receptor (sCD14), and high-sensitivity CRP (hs-CRP). 192 individuals, aged 40-59 years (61 white (30 women), 68 of African origin (33 women) and 63 South Asians (33 women)), free from coronary heart disease (CHD), stroke, CVD and diabetes were randomly selected from the UK 'Wandsworth Heart and Stroke Study'.Results: Age-adjusted endotoxin levels were lower in women than in men (p=0.002) and were highest in South Asians (13.3 EU/mL [95% CI 12.0-14.7]) and lowest in individuals of African origin (10.1 EU/mL [9.1-11.1]) than in whites (p for linear trend