Delicately Designed Cancer Cell Membrane-Camouflaged Nanoparticles for Targeted 19F MR/PA/FL Imaging-Guided Photothermal Therapy
Delicately Designed Cancer Cell Membrane-Camouflaged Nanoparticles for Targeted 19F MR/PA/FL Imaging-Guided Photothermal Therapy
复制标题
精心设计的癌细胞膜伪装纳米粒子，用于靶向 19F MR/PA/FL 成像引导光热治疗
DOI：
10.1021/acsami.0c13865
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发表时间：
2020-12-23
影响因子：
9.5
通讯作者：
Zhou, Xin
中科院分区：
文献类型：
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作者：
Li, Sha;Jiang, Weiping;Zhou, Xin
我们对多模式纳米探针的探索旨在结合光声（PA）成像，F-19磁共振（MR）和荧光（FL）成像，该成像提供了互补的优势，例如高空间分辨率，无限渗透性渗透和高灵敏度，以使更精致的图像启用准确的图像以获得准确的图像诊断。在这项研究中，用于插入室内F-19的MR/ FL/ PA三模式成像指导指导的光热治疗的聚（乳酸 - 乙醇酸）（PLGA）封装了全氟化合物（PFC）和吲哚氰氨基绿色（ICG）。然后，将其涂有A549癌细胞膜（AM），以制造多功能溶液纳米探针（AM-PPP@ICGNPS）。在全身给药后，FLI揭示了具有高灵敏度的NP的时间依赖性肿瘤归巢，19 F MRI提供了NP的肿瘤定位而无需背景信号干扰，并且PM说明了NP的详细分布，具有高空间分辨率。更重要的是，在肿瘤区域中积累的AM-PP@ICGNP在近红外（NIR）激光照射下表现出明显的光热效应（48.4摄氏度），并在体内实现增强的抗肿瘤反应。这些好处与出色的生物相容性相结合，使AM-PP@ICGNP成为潜在的疗法纳米剂，以进行准确的肿瘤定位，并最终实现出色的癌症治疗。
Our exploration of multimodal nanoprobes aims to combine photoacoustic (PA) imaging, F-19 magnetic resonance (MR), and fluorescence (FL) imaging, which offers complementary advantages such as high spatial resolution, unlimited penetration, and high sensitivity to enable more refined images for accurate tumor diagnoses. In this research, perfluorocarbons (PFCs) and indocyanine green (ICG) are encapsulated by poly(lactic-co-glycolic acid) (PLGA) for intravital F-19 MR/FL/ PA tri-modal imaging-guided photothermal therapy. Then, it is coated with an A549 cancer cell membrane (AM) to fabricate versatile theranostic nanoprobes (AM-PP@ICGNPs). After systemic administration, FLI reveals time-dependent tumor homing of NPs with high sensitivity, 19 F MRI provides tumor localization of NPs without background signal interference, and PM illustrates the detailed distribution of NPs inside the tumor with high spatial resolution. What is more, AM-PP@ICGNPs accumulated in the tumor area exhibit a prominent photothermal effect (48.4 degrees C) under near infrared (NIR) laser irradiation and realize an enhanced antitumor response in vivo. These benefits, in combination with the excellent biocompatibility, make AM-PP@ICGNPs a potential theranostic nanoagent for accurate tumor localization and ultimately achieve superior cancer therapy.