Hydrated Phospholipid Polymer Gel-Like Layer for Increased Durability of Orthopedic Bearing Surfaces
Hydrated Phospholipid Polymer Gel-Like Layer for Increased Durability of Orthopedic Bearing Surfaces
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水合磷脂聚合物凝胶状层可提高骨科轴承表面的耐用性
DOI：
10.1021/acs.langmuir.8b01494
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发表时间：
2018
期刊：
影响因子：
3.9
通讯作者：
Ishihara Kazuhiko
中科院分区：
文献类型：
--
作者：
Kyomoto Masayuki;Moro Toru;Yamane Shihori;Watanabe Kenichi;Hashimoto Masami;Tanaka Sakae;Ishihara Kazuhiko
最近，用于操纵骨科关节面基材的传统策略已尝试通过交联和抗氧化剂共混来调节聚乙烯基材以提高其耐磨性。然而，需要进一步研究的基板，以及表面的结构和关节软骨的作用集中。因此，我们开发了一种骨科关节面，通过接枝高度亲水性的聚（2-甲基丙烯酰氧乙基磷酸胆碱），包括纳米级的水合凝胶状层，其目的是模仿关节软骨的润滑机制，并研究其表面特性，体积特性，以及在加速老化后的承重条件下的行为。凝胶状表面的亲水性和润滑性均不受加速老化的影响;相反，即使在强氧化条件下，也显示出高稳定性。水合凝胶状表面的特征增强了交联聚乙烯内衬的耐磨性，与加速老化无关。这些结果表明，即使在承重条件下，水合凝胶状表面也能延长交联聚乙烯关节面的寿命。此外，磨损的时间序列上的拐点可以是终身保护剂的耐久性的合适指标。总之，水合凝胶状表面可以积极地增加骨科植入物的耐久性。
Recently, traditional strategies for manipulating orthopedic bearing substrates have attempted to improve their wear resistance by adjusting polyethylene substrate through cross-linking and antioxidant blending. However, further research is required on the substrate, as well as the surface focused on the structure and role of articular cartilage. We therefore develop an orthopedic bearing surface comprising a nanometer-scale hydrated gel-like layer by grafting highly hydrophilic poly(2-methacryloyloxyethyl phosphorylcholine), with the aim of mimicking the lubrication mechanism of articular cartilage, and investigate its surface characteristics, bulk characteristics, and behavior under load bearing conditions upon accelerated aging. Neither the hydrophilicity nor lubricity of the gel-like surface was influenced by accelerated aging; instead, high stability was revealed, even under strong oxidation conditions. The characteristics of the hydrated gel-like surface potentiated the wear resistance of the cross-linked polyethylene liner, irrespective of accelerated aging. These results suggest that the hydrated gel-like surface enhances the longevity of cross-linked polyethylene bearings even under load-bearing conditions. Furthermore, the inflection point on the time series of wear can be a suitable indicator of the durability of the life-long protectant. In conclusion, the hydrated gel-like surface can positively increase orthopedic implant durability.