Evaluation of Retinal Nerve Fiber Layer Progression in Glaucoma A Prospective Analysis with Neuroretinal Rim and Visual Field Progression
Evaluation of Retinal Nerve Fiber Layer Progression in Glaucoma A Prospective Analysis with Neuroretinal Rim and Visual Field Progression
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DOI：
10.1016/j.ophtha.2010.12.035
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发表时间：
2011-08-01
期刊：
影响因子：
13.7
通讯作者：
Lam, Dennis Shun Chiu
中科院分区：
文献类型：
--
作者：
Leung, Christopher Kai Shun;Liu, Shu;Lam, Dennis Shun Chiu
目的：评价青光眼进展检测的性能和视网膜神经纤维层（RNFL）、神经视网膜边缘和视野测量的变化率。设计：前瞻性研究。参与者：70例青光眼患者的108只眼。方法：患者每4个月随访一次，至少随访2.9年使用Stratus光学相干断层扫描仪（OCT）测量RNFL厚度（中位数，3.2年）（Carl Zeiss Meditec，都柏林，CA），使用海德堡视网膜断层扫描仪的神经视网膜边缘区域（HRT 3; Heidelberg Engineering，GmbH，Dossen-heim，德国），以及Humphrey Field Analyzer II（Carl Zeiss Meditec）视野。在视野指数（VFI）、RNFL和神经视网膜边缘测量值与年龄之间进行线性回归分析，当检测到显著的负趋势时定义为进展。采用kappa统计评估结构和功能测量之间的一致性。平均变化率估计与线性mixed modeling.Main结果Measures：协议进展检测和RNFL，neuroretinal rim，和VFI measurements.Results的变化率：共1105 OCT，1062 HRT，和1099视野测量进行了分析。3项研究中进展检测的一致性较差（kappa
Objective: To evaluate the performance of progression detection and the rate of change of retinal nerve fiber layer (RNFL), neuroretinal rim, and visual field measurements in glaucoma.Design: Prospective study.Participants: One hundred eight eyes of 70 glaucoma patients.Methods: Patients were followed up every 4 months for at least 2.9 years (median, 3.2 years) for measurement of RNFL thickness with the Stratus optical coherence tomograph (OCT) (Carl Zeiss Meditec, Dublin, CA), neuroretinal rim area with the Heidelberg Retinal Tomograph (HRT 3; Heidelberg Engineering, GmbH, Dossen-heim, Germany), and visual field with the Humphrey Field Analyzer II (Carl Zeiss Meditec). Linear regression analyses were performed between visual field index (VFI), RNFL, and neuroretinal rim measurements and age, with progression defined when a significant negative trend was detected. The agreement among structural and functional measurements was evaluated with kappa statistics. The mean rate of change was estimated with linear mixed modeling.Main Outcome Measures: The agreement on progression detection and the rate of change of RNFL, neuroretinal rim, and VFI measurements.Results: A total of 1105 OCT, 1062 HRT, and 1099 visual field measurements were analyzed. The agreement of progression detection among the 3 investigations was poor (kappa