MALIGNANT MESOTHELIOMA IN CHILDREN - REPORT OF 7 CASES AND REVIEW OF THE LITERATURE
MALIGNANT MESOTHELIOMA IN CHILDREN - REPORT OF 7 CASES AND REVIEW OF THE LITERATURE
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DOI：
10.1002/mpo.2950090409
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发表时间：
1981-01-01
期刊：
影响因子：
--
通讯作者：
MAGILL, GB
中科院分区：
文献类型：
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作者：
BRENNER, J;SORDILLO, PP;MAGILL, GB
自1953年以来共收治7例恶性间皮瘤患儿。6例起源于胸膜，1例起源于腹膜。所有患者均无接触石棉的病史。两名患者已存活5年。其余5例患者在确诊后2年内死亡。4例患者有远处转移，其中3例有脑转移。在大多数患者中，手术或放射治疗对控制疾病无效。1例患者对阿霉素、环磷酰胺和长春新碱的联合治疗完全有效，并已5年半无病。这7例与文献中报道的其他42例儿童恶性间皮瘤一样被复习。
Seven children with malignant mesothelioma were seen since 1953. In 6 the origin was at the pleura and in 1 at the peritoneum. None of the patients related a history of exposure to asbestos. Two patients lived > 5 yr. The other 5 patients died within 2 yr of diagnosis. Distant metastases were seen in 4 of the patients, including 3 who had metastases to brain. Surgery or radiotherapy was not effective in controlling the disease in most of the patients. One patient had a complete response to a combination of adriamycin, cyclophosphamide and vincristine and has remained free of disease for 5 1/2 yr. The 7 cases are reviewed as are the other 42 cases of malignant mesothelioma in children reported in the literature.