THE IMMUNOPATHOGENESIS AND REGULATION OF T-CELL-MEDIATED DEMYELINATING DISEASES
THE IMMUNOPATHOGENESIS AND REGULATION OF T-CELL-MEDIATED DEMYELINATING DISEASES
复制标题
DOI：
10.1016/0167-5699(94)90173-2
复制
发表时间：
1994-08-01
期刊：
影响因子：
--
通讯作者：
KARPUS, WJ
中科院分区：
文献类型：
--
作者：
MILLER, SD;KARPUS, WJ
目前正在评估各种实验方法来控制CD4（+）辅助性T细胞1（Th1）介导的自身免疫病理学。在这里，斯蒂芬米勒和威廉Karpus比较和对比各种抗原特异性调节策略的功效。特别强调的是外周免疫耐受的机制，这可能是如何用于治疗和分析的病理性T细胞库的自身免疫性和病毒诱导的脱髓鞘疾病。
A variety of experimental approaches are currently being evaluated for controlling CD4(+) T helper 1 (Th1)-mediated autoimmune pathology. Here, Stephen Miller and william Karpus compare and contrast the efficacies of various antigen-specific regulatory strategies. Particular emphasis is placed on the mechanisms of peripheral immune tolerance and how this may be used in the treatment and analysis of the pathologic T-cell repertoire in autoimmune and virus-induced demyelinating diseases.