Complete gene map of the plastid-like DNA of the malaria parasite Plasmodium falciparum
Complete gene map of the plastid-like DNA of the malaria parasite Plasmodium falciparum
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DOI：
10.1006/jmbi.1996.0449
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发表时间：
1996-08-16
影响因子：
5.6
通讯作者：
Williamson, DH
中科院分区：
文献类型：
--
作者：
Wilson, RJM;Denny, PW;Williamson, DH
疟疾寄生虫和其他顶复合体门的寄生原生生物携带一个类似质体的基因组，其序列复杂性大大降低。这个35 kb的DNA环类似于非光合植物的质体DNA，几乎完全编码与基因表达有关的成分。这里描述的完整基因图谱包括复制大小亚基rnas的基因，25种tRNA，真细菌RNA聚合酶的3个亚基，17种核糖体蛋白和翻译延伸因子。此外，它还编码了一个不寻常的Clp家族伴侣成员，以及一个在红藻质体中发现的未知功能的开放阅读框。转录是多反式的。这种质体样DNA分子在顶复合体的几个属中是保守的，据推测是由门的一个早期祖先通过次生内共生获得的。携带这种DNA的细胞器（质体）的功能仍然不清楚，但似乎是由转移到细胞核的基因指定的。(C) 1996学术出版社有限公司
Malaria parasites, and other parasitic protists of the Phylum Apicomplexa, carry a plastid-like genome with greatly reduced sequence complexity. This 35 kb DNA circle resembles the plastid DNA of non-photosynthetic plants, encoding almost exclusively components involved in gene expression. The complete gene map described here includes genes for duplicated large and small subunit rRNAs, 25 species of tRNA, three subunits of a eubacterial RNA polymerase, 17 ribosomal proteins, and a translation elongation factor. In addition, it codes for an unusual member of the Clp family of chaperones, as well as an open reading frame of unknown function found in red algal plastids. Transcription is polycistronic. This plastid-like DNA molecule is conserved in several genera of apicomplexans and is conjectured to have been acquired by an early progenitor of the Phylum by secondary endosymbiosis. The function of the organelle (plastid) carrying this DNA remains obscure, but appears to be specified by genes transferred to the nucleus. (C) 1996 Academic Press Limited