Kinesin: walking, crawling or sliding along?
Kinesin: walking, crawling or sliding along?
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DOI：
10.1016/j.tcb.2004.12.007
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发表时间：
2005-02
影响因子：
19
通讯作者：
A. Yildiz;P. Selvin
中科院分区：
文献类型：
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作者：
A. Yildiz;P. Selvin
动蛋白是一种以微管为基础的马达蛋白，参与货物运输和有丝分裂。它们被称为‘马达’，因为它们将化学能转化为机械能(即力和运动)。它们通过在微管上行走，将ATP水解酶的能量用于酶的过程。然而，他们的动议背后的机制一直不清楚。最近，传统的动蛋白是该家族中第一个被发现的成员，它被证明是通过交换它的两个头来行走的，这是一种手到手的机制。也有实验证据支持动蛋白的不对称行走，在这种情况下，马达的两个相同的头部交替地走慢步和快步。其他运载货物和有丝分裂的动蛋白仍未被研究，生物物理学家对此非常感兴趣。
Kinesins are microtubule-based motor proteins that are involved in cargo transport and mitosis. They are called ‘motors' because they convert chemical energy to mechanical energy (i.e. force and motion). They use the energy of ATP hydrolysis for their enzymatic processes by walking on microtubules. However, the mechanism underlying their motion has been unclear. Recently, conventional kinesin, which was the first-identified member of the family, has been shown to walk by swapping its two heads in a ‘hand-over-hand' mechanism. There is also experimental evidence supporting an asymmetric walking of kinesin in which two identical heads of the motor take alternate slow and fast steps. Other cargo-carrier and mitotic kinesins remain uninvestigated and are of great interest to biophysicists.