Chemoselective Synthesis of Uniform Sequence-Coded Polyurethanes and Their Use as Molecular Tags
Chemoselective Synthesis of Uniform Sequence-Coded Polyurethanes and Their Use as Molecular Tags
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DOI：
10.1016/j.chempr.2016.06.006
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发表时间：
2016-07-07
期刊：
影响因子：
23.5
通讯作者：
Lutz, Jean-Francois
中科院分区：
文献类型：
--
作者：
Gunay, Ufuk Saim;Petit, Benoit Eric;Lutz, Jean-Francois
聚氨酯 (PU) 是一类流行的塑料材料，在建筑、涂料和汽车行业有着广泛的应用。 PU 通常是通过逐步生长聚合合成的，因此表现出不均匀的分子结构。在这里，我们证明可以通过简单的化学选择性多步生长方法来制备均匀的 PU。该策略允许精确控制所形成的PU的链长及其一级结构，从而使得编码单体序列的制备成为可能。此外，我们发现这些聚合物非常容易通过串联质谱测序进行分析。因此，这些精密聚合物有可能在各种应用中用作分子条形码。作为概念证明，这里报告了它们作为材料识别的防伪标签的用途。
Polyurethanes (PUs) constitute a popular class of plastic materials with a wide range of applications in construction, coatings, and the automotive industry. PUs are usually synthesized by step-growth polymerization and, therefore, exhibit non-uniform molecular structures. Here, we show that uniform PUs can be prepared by a facile chemoselective multistep-growth approach. This strategy permits precise control of the chain lengths of the PUs formed and their primary structure, thus making the preparation of coded monomer sequences possible. Furthermore, it was found that these polymers are remarkably easy to analyze by tandem mass spectrometry sequencing. Thus, these precision polymers can potentially be used as molecular barcodes in various applications. As a proof of concept, their use as anti-counterfeiting tags for identification of materials is reported here.