Neural plasticity, neuropeptides and anxiety in animals - implications for understanding and treating affective disorder following traumatic stress in humans
Neural plasticity, neuropeptides and anxiety in animals - implications for understanding and treating affective disorder following traumatic stress in humans
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DOI：
10.1016/s0149-7634(98)00032-3
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发表时间：
1998-12-01
影响因子：
8.2
通讯作者：
Merali, Z
中科院分区：
文献类型：
--
作者：
Adamec, R;Kent, P;Merali, Z
大鼠暴露于猫（捕食者应激）持久增加啮齿动物焦虑样行为（ALB）在高架十字迷宫。先前的工作表明，持续的变化，在ALE捕食压力依赖于NMDA和CCKB受体。在本文中，我们描述了不同程度的捕食者暴露行为的影响。影响取决于行为措施。一般来说，与无保护地接触猫相比，接触捕食者气味对ALE持久变化的刺激性较小。此外，我们还研究了无保护地接触捕食者的影响随着时间的推移而发展。对ALE的持续影响开始于捕食者应激后30 min至1 h，并持续至少3周。我们还报告了一个复杂的模式捕食者压力的影响，神经内分泌和应激肽（蛙皮素，CRF和AVP）水平在各种大脑区域。毫不奇怪，捕食者暴露增加血浆皮质酮和ACTH水平。还注意到下丘脑-垂体轴、相关下丘脑核、边缘系统和脑干区域中肽含量的中枢变化。最后，通径分析显示猫的行为、大鼠的防御行为与一周后的ALE增加程度之间存在可复制的关系。有人提出，捕食者压力后的行为变化可能与PTSD相关的焦虑模型。(C)1998爱思唯尔科技有限公司保留所有权利。
Exposure of rats to cats (predator stress) lastingly increases rodent anxiety-like behavior (ALB) in the elevated plus-maze. Previous work shows that lasting changes in ALE following predator stress depend on NMDA and CCKB receptors. In this paper we describe the effects of differing degrees of predator exposure on behavior. Effects depend on the behavioral measure. In general, exposure to predator odor is less provocative of lasting change in ALE than is unprotected exposure to a cat. In addition, we examine the development of effects of unprotected predator exposure over time. Lasting effects on ALE begin at 30 min to 1 h after predator stress and persist for at least 3 weeks. We also report a complex pattern of effects of predator stress on neuroendocrine and stress peptide (bombesin, CRF and AVP) levels in a variety of brain areas. Not surprisingly, predator exposure increases plasma levels of corticosterone and ACTH. Central changes in peptide content in the hypothalamo-pituitary axis, related hypothalamic nuclei, limbic and brain stem areas are also noted. Finally, path analysis demonstrates a replicable relationship between cat behavior, rat defensive behavior and degree of increase in ALE one week later. It is proposed that behavioral changes following predator stress may model anxiety associated with PTSD. (C) 1998 Elsevier Science Ltd. All ri hts reserved.