Drosophila retained/dead ringer is necessary for neuronal pathfinding, female receptivity and repression of fruitless independent male courtship behaviors
Drosophila retained/dead ringer is necessary for neuronal pathfinding, female receptivity and repression of fruitless independent male courtship behaviors
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DOI：
10.1242/dev.01568
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发表时间：
2005-01-01
期刊：
影响因子：
4.6
通讯作者：
McKeown, M
中科院分区：
文献类型：
--
作者：
Ditch, LM;Shirangi, T;McKeown, M
果蝇retained/dead ringer（retn）基因突变导致雌性行为缺陷，并改变CNS中有限的神经元。RETN被认为是在无结果（Fru）雄性蛋白不存在时雄性求偶行为的主要抑制物。RETN雌性表现出与雄性和雌性类似的求偶行为，并且对雄性的求偶行为具有高度抗性。男性retn突变与正常参数法院，虽然女性化的retn细胞在男性诱导双性恋。选择性剪接RNA出现在幼虫和蛹的中枢神经系统，但没有显示性别特异性。胚胎后，retn RNA在CNS和眼睛中的一组有限的神经元中表达。retn突变细胞的神经缺陷包括蘑菇体β叶融合和光感受器和食管下神经元的寻路错误。我们证实，这些表达retn的细胞中的一些细胞具有抑制由fru（M）激活的雄性行为途径的功能。
Mutations in the Drosophila retained/dead ringer (retn) gene lead to female behavioral defects and alter a limited set of neurons in the CNS. retn is implicated as a major repressor of male courtship behavior in the absence of the fruitless (fru) male protein. retn females show fru-independent male-like courtship of males and females, and are highly resistant to courtship by males. Males mutant for retn court with normal parameters, although feminization of retn cells in males induces bisexuality. Alternatively spliced RNAs appear in the larval and pupal CNS, but none shows sex specificity. Post-embryonically, retn RNAs are expressed in a limited set of neurons in the CNS and eyes. Neural defects of retn mutant cells include mushroom body beta-lobe fusion and pathfinding errors by photoreceptor and subesophageal neurons. We posit that some of these retn-expressing cells function to repress a male behavioral pathway activated by fru(M).