Peptide-small, molecule hybrids via orthogonal deprotection-chemoselective conjugation to cysteine-anchored scaffolds. A model study
Peptide-small, molecule hybrids via orthogonal deprotection-chemoselective conjugation to cysteine-anchored scaffolds. A model study
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DOI：
10.1021/ol026736d
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发表时间：
2002-11-14
期刊：
影响因子：
5.2
通讯作者：
Chaiken, IM
中科院分区：
文献类型：
--
作者：
Smith, AB;Savinov, SN;Chaiken, IM
[图形]正交脱保护-缀合方案的可行性，持有连接到半胱氨酸锚定肽支架的功能多样的化学探针库的承诺，已经用模型系统进行了探索。已经准备了组装杂交文库所需的工具，并优化了串联程序。S-烷基化和S-亚磺酰基化是具有化学选择性的连接反应。
[GRAPHICS]The feasibility of an orthogonal deprotection-conjugation protocol, holding the promise of libraries of functionally diverse chemical probes attached to cysteine-anchored peptide scaffolds, has been explored with a model system. The necessary tools for assembly of the hybrid libraries have been prepared and the tandem procedure optimized. S-Alkylation and S-sulfenylation are featured as the chemoselective ligation reactions.