Effect of zinc supplementation on mortality in children aged 1-48 months: a community-based randomised placebo-controlled trial
Effect of zinc supplementation on mortality in children aged 1-48 months: a community-based randomised placebo-controlled trial
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DOI：
10.1016/s0140-6736(07)60452-8
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发表时间：
2007-03-17
期刊：
影响因子：
168.9
通讯作者：
Kabole, Fatma M.
中科院分区：
文献类型：
--
作者：
Sazawal, Sunil;Black, Robert E.;Kabole, Fatma M.
来自亚洲的研究表明，锌补充剂可以降低儿童的发病率和死亡率，但来自非洲疟疾流行人群的证据并不一致。我们的目的是评估补锌对儿童总体死亡率的影响，在奔巴，桑给巴尔。方法我们招募了42 546名儿童，年龄在1-36个月，共贡献了56 507儿童年的随机，双盲，安慰剂对照试验在奔巴，桑给巴尔。按家庭进行随机化。21274名儿童每天补充锌10 mg（12个月以下儿童5 mg），平均484.7天（SD 306.6）。21272接受安慰剂。主要终点是总死亡率，分析是通过意向治疗进行的。该研究注册为国际标准随机临床试验，编号ISRCTN 59549825。（95% CI-6%~ 19%; p=0.29）与补锌相关的全因死亡率的相对风险降低。对所有关于死亡率和发病率的研究进行分析，将有助于就补锌在公共卫生政策中的作用提出循证建议，以改善幼儿的死亡率、发病率、生长和发育。
Background Studies from Asia have suggested that zinc supplementation can reduce morbidity and mortality in children, but evidence from malarious populations in Africa has been inconsistent. Our aim was to assess the effects of zinc supplementation on overall mortality in children in Pemba, Zanzibar.Methods We enrolled 42 546 children aged 1-36 months, contributing a total of 56 507 child-years in a randomised, double-blind, placebo-controlled trial in Pemba, Zanzibar. Randomisation was by household. 21274 children received daily supplementation with zinc 10 mg (5 mg in children younger than 12 months) for mean 484.7 days (SD 306.6). 21272 received placebo. The primary endpoint was overall mortality, and analysis was by intention to treat. This study is registered as an International Standard Randomised Clinical Trial, number ISRCTN59549825.Findings Overall, there was a non-significant 7% (95% CI -6% to 19%; p=0.29) reduction in the relative risk of all-cause mortality associated with zinc supplementation.Interpretation We believe that a meta-analysis of all studies of mortality and morbidity, will help to make evidence-based recommendations for the role of zinc supplementation in public health policy to improve mortality, morbidity; growth, and development in young children.