Abnormal axonal inward rectification in diabetic neuropathy
Abnormal axonal inward rectification in diabetic neuropathy
复制标题
糖尿病神经病变的轴突向内矫正异常
作者：
S. Horn;S. Quasthoff;P. Grafe;H. Bostock;Rolf Renner;B. Schrank
异常的轴突膜电导可能导致人类糖尿病神经病变。为了检验这个想法，我们比较了 63 名糖尿病患者、50 名正常对照者和 27 名肌萎缩侧索硬化症 (ALS) 患者的手腕正中运动和感觉轴突施加持久（100-200 毫秒）去极化和超极化电流所产生的阈值变化。糖尿病患者运动和感觉轴突的阈值电紧张图的平均值显示，在应用超极化电流期间，亚兴奋性更高，并且在应用超极化电流后恢复更慢。以前在用铯离子抑制轴突向内整流后在离体大鼠神经中发现了这种改变。糖尿病患者的异常与患者的年龄和神经病变的存在呈正相关。糖尿病中观察到的阈值电紧张与急性缺血的影响有很大不同，并且与 ALS 中记录的变化不同。数据表明，外周轴突的异常向内矫正与糖尿病神经病变相关。更好地了解这种电导的神经生物学可能会提供有关这种疾病的病理生理学的信息。 © 1996 约翰威利父子公司。
An abnormal axonal membrane conductance might contribute to human diabetic neuropathy. To test this idea, we have compared the threshold changes produced by long‐lasting (100–200 ms) de‐ and hyperpolarizing currents applied to median motor and sensory axons at the wrist in 63 diabetic patients with those from 50 normal controls and 27 amyotrophic lateral sclerosis (ALS) patients. Averages of the threshold electrotonus plots for motor and sensory axons of diabetic patients showed more subexcitability during, and slower recovery following, the application of hyperpolarizing currents. Such alterations have been previously found in isolated rat nerves after inhibition of axonal inward rectification by means of cesium ions. The abnormalities in diabetics were positively correlated with the age of patients and the presence of neuropathy. Threshold electrotonus seen in diabetes differed strongly from the effects of acute ischemia and were unlike changes recorded in ALS. The data indicate that an abnormal inward rectification of peripheral axons is associated with diabetic neuropathy. A better understanding of the neurobiology of this conductance might provide information about the pathophysiology of this disease. © 1996 John Wiley & Sons, Inc.
糖尿病神经病变中皮肤传入的特性。
DOI：
10.1093/brain/112.5.1359
发表时间：
1989
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Mackel,R
通讯作者：
Mackel,R
影响因子：
2.5
作者：
SPAIN, WJ;SCHWINDT, PC;CRILL, WE
通讯作者：
CRILL, WE