Subset specificity of antilymhocyte antibodies in systemic lupus erythematosus. II. Preferential reactivity with T4 + cells is associated with relative depletion of autologous T4 + cells.
Subset specificity of antilymhocyte antibodies in systemic lupus erythematosus. II. Preferential reactivity with T4 + cells is associated with relative depletion of autologous T4 + cells.
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系统性红斑狼疮抗淋巴细胞抗体的亚组特异性。
DOI：
10.1002/art.1780300206
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发表时间：
1987
影响因子：
--
通讯作者：
Minota,S
中科院分区：
文献类型：
--
作者：
Winfield,JB;Shaw,M;Yamada,A;Minota,S
使用间接免疫荧光和流式细胞术，我们测定了血清冷反应性抗淋巴细胞抗体阳性的系统性红斑狼疮患者外周血中T3+、T4+和T8+细胞的比例和数量，以及血清这些抗体阴性的患者的值。当自体血清中存在对该亚群具有优先细胞毒性的冷反应性抗淋巴细胞抗体时，T4+外周淋巴细胞出现不成比例的减少。该亚群的减少导致T4：T8比值降低; T8+细胞数量和比例的变化不显著。在接受泼尼松治疗的患者中发现了T4+亚群的类似但不依赖于自身抗体的改变。未观察到T细胞群异常与系统性红斑狼疮疾病活动本身之间的关系。
Using indirect immunofluorescence and flow cytometry, we determined the proportion and number of T3+, T4+, and T8+ cells in the peripheral blood of patients with systemic lupus erythematosus whose sera were positive for cold‐reactive antilymphocyte antibodies versus values in patients whose sera were negative for these antibodies. There was a disproportionate reduction in T4+ peripheral lymphocytes when cold‐reactive antilymphocyte antibodies preferentially cytotoxic for this subpopulation were present in autologous serum. The decrease in this subset was responsible for a reduction in the T4:T8 ratio; variation in the number and proportion of T8+ cells was insignificant. A similar, but autoantibody‐independent, alteration in the T4+ subpopulation was found in patients who were receiving prednisone therapy. A relationship between T cell population abnormalities and systemic lupus erythematosus disease activity, per se, was not observed.