Mollanol A, a Diterpenoid with a New C-Nor-D-homograyanane Skeleton from the Fruits of Rhododendron molle
Mollanol A, a Diterpenoid with a New C-Nor-D-homograyanane Skeleton from the Fruits of Rhododendron molle
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Mollanol A，一种来自杜鹃果实的具有新 C-Nor-D-homograyanane 骨架的二萜类化合物
DOI：
10.1021/ol5020653
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发表时间：
2014-08-15
期刊：
影响因子：
5.2
通讯作者：
Yu, Shi-Shan
中科院分区：
文献类型：
--
作者：
Li, Yong;Liu, Yun-Bao;Yu, Shi-Shan
从杜鹃（Rhododendron molle）果实中分离到两个新的灰色类化合物mollanol A(1)和rhodomollein XXV(2)。用光谱学方法和x射线衍射分析对其结构进行了鉴定。Mollanol A(1)具有新的c -no - d -homograyanane碳骨架，而rhodomollein XXV(2)是第一个11,16-环氧grayanane的例子，具有笼状的氧环[3.3.1.0(3.7)]壬烷环体系。提出了1的合理生物遗传途径。化合物1在IEC-6、293T和RAW264.7细胞中表现出对xbp1上游启动子的转录激活作用。
Two new grayanoids, mollanol A (1) and rhodomollein XXV (2), were isolated from the fruits of Rhododendron molle. Their structures were elucidated by spectroscopic methods and X-ray diffraction analyses. Mollanol A (1) possesses a new C-nor-D-homograyanane carbon skeleton, while rhodomollein XXV (2) is the first example of an 11,16-epoxygrayanane and features a caged oxatricyclo[3.3.1.0(3.7)]nonane ring system. Plausible biogenetic pathways for 1 were proposed. Compound 1 exhibited transcriptional activation effects on the xbp1 upstream promoter in IEC-6, 293T, and RAW264.7 cells.