Magnetothermal Multiplexing for Selective Remote Control of Cell Signaling
Magnetothermal Multiplexing for Selective Remote Control of Cell Signaling
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DOI：
10.1002/adfm.202000577
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发表时间：
2020-07-10
影响因子：
19
通讯作者：
Anikeeva, Polina
中科院分区：
文献类型：
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作者：
Moon, Junsang;Christiansen, Michael G.;Anikeeva, Polina
磁性纳米粒子在生物医学应用中的前景，包括诊断成像，触发药物释放，癌症热疗和神经刺激，已经获得了持续的研究兴趣。这些应用中的许多应用利用铁氧体纳米颗粒在交变磁场下的散热，这些磁场充当存在或不存在的外部管理刺激，打开和关闭散热。在这里，这一概念的延伸，磁热多路复用被证明，其中暴露于不同幅度和频率的交变磁场可以导致磁性纳米颗粒集合的选择性和独立加热。这些颗粒的不同磁性，经验上由定制的高振幅交流磁力计表征，告知了多路复用材料系统的系统选择。这项工作的高潮在磁热多路复用在体外细胞信号的选择性远程控制演示。
Magnetic nanoparticles have garnered sustained research interest for their promise in biomedical applications including diagnostic imaging, triggered drug release, cancer hyperthermia, and neural stimulation. Many of these applications make use of heat dissipation by ferrite nanoparticles under alternating magnetic fields, with these fields acting as an externally administered stimulus that is either present or absent, toggling heat dissipation on and off. Here, an extension of this concept, magnetothermal multiplexing is demonstrated, in which exposure to alternating magnetic fields of differing amplitude and frequency can result in selective and independent heating of magnetic nanoparticle ensembles. The differing magnetic coercivity of these particles, empirically characterized by a custom high amplitude alternating current magnetometer, informs the systematic selection of a multiplexed material system. This work culminates in a demonstration of magnetothermal multiplexing for selective remote control of cellular signaling in vitro.