Analysis of the Damage Mechanism Related to CO(2) Laser Cochleostomy on Guinea Pig Cochlea.
Analysis of the Damage Mechanism Related to CO(2) Laser Cochleostomy on Guinea Pig Cochlea.
复制标题
CO2激光耳蜗造口术对豚鼠耳蜗损伤机制的分析。
DOI：
10.1155/2016/5982397
复制
发表时间：
2016
影响因子：
3.1
通讯作者：
Ren DD
中科院分区：
文献类型：
--
作者：
Liu X;Qian XQ;Ma R;Chi FL;Ren DD
Different types of lasers have been used in inner ear surgery. Therefore, it is of the utmost importance to avoid damage to the inner ear (e.g., hyperthermia and acoustic effects) caused by the use of such lasers. The aim of this study was to use a high powered fibre-enabled CO2 laser (10 W, 606 J/cm2) to perform cochleostomies on guinea pig cochlea and to investigate the possible laser-induced damage mechanisms. The temperature changes in the round window membrane, auditory evoked brainstem response, and morphological of the hair cells were measured and recorded before and after laser application. All of the outcomes differed in comparison with the control group. A rise in temperature and subsequent increased hearing loss were observed in animals that underwent surgery with a 10 W CO2 laser. These findings correlated with increased injury to the cochlear ultrastructure and a higher positive expression of E-cadherin and β-catenin in the damaged organ of Corti. We assume that enhanced cell-cell adhesion and the activated β-catenin-related canonical Wnt-signalling pathway may play a role in the protection of the cochlea to prevent further damage.
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影响因子：
2.6
作者：
Kamalski, Digna M. A.;Verdaasdonk, Rudolf M.;Grolman, Wilko
通讯作者：
Grolman, Wilko
影响因子：
5.3
作者：
Karpowicz, Phillip;Willaime-Morawek, Sandrine;van der Kooy, Derek
通讯作者：
van der Kooy, Derek
影响因子：
2.1
作者：
Kiefer, J;Tillein, T;Gstoettner, W
通讯作者：
Gstoettner, W
影响因子：
2.6
作者：
Remacle, Marc;Ricci-Maccarini, Andrea;Nollevaux, Marie-Cecile
通讯作者：
Nollevaux, Marie-Cecile
影响因子：
1.7
作者：
Ren, DD;Sun, JW;Shen, F
通讯作者：
Shen, F