How to determine the permeability for cement infiltration of osteoporotic cancellous bone
How to determine the permeability for cement infiltration of osteoporotic cancellous bone
复制标题
DOI：
10.1016/s1350-4533(02)00223-0
复制
发表时间：
2003-05-01
影响因子：
2.2
通讯作者：
Steffen, T
中科院分区：
文献类型：
--
作者：
Baroud, G;Wu, JZ;Steffen, T
骨水泥强化是一种新兴的外科手术，其中骨水泥被用于渗透和加固骨质疏松的椎骨。尽管这种渗透手术已被广泛应用，但它是凭经验进行的，并且在注射过程中骨水泥的流动特性鲜为人知。我们提出了一种理论和实验方法来研究渗透过程中骨小梁间的渗透性。在我们的分析中，骨水泥的渗透性被认为取决于时间、骨孔隙率和骨水泥的粘度。为了确定与时间相关的渗透性，从骨质疏松的椎骨中获取了10个松质骨芯，以恒定流速用丙烯酸骨水泥进行渗透，并测量了渗透过程中骨芯两端的压降。渗透性对粘度的依赖性是根据已发表的实验数据确定的。然后将渗透性作为骨孔隙率和时间的函数的理论模型与测试数据进行拟合。我们的研究结果表明，骨小梁间的渗透性强烈依赖于时间。例如，初始渗透性（60.89平方毫米的四次方/牛·秒）在18秒内降低到其原始值的约63%。这项研究是首次分析骨水泥在骨质疏松骨中的流动。本文提供的理论和实验模型具有通用性。因此，它们可用于系统地研究和优化临床实践中的渗透过程。（C）2003年英国医学工程学会。由爱思唯尔科学有限公司出版。保留所有权利。
Cement augmentation is an emerging surgical procedure in which bone cement is used to infiltrate and reinforce osteoporotic vertebrae. Although this infiltration procedure has been widely applied, it is performed empirically and little is known about the flow characteristics of cement during the injection process. We present a theoretical and experimental approach to investigate the intertrabecular bone permeability during the infiltration procedure. The cement permeability was considered to be dependent on time, bone porosity, and cement viscosity in our analysis. In order to determine the time-dependent permeability, ten cancellous bone cores were harvested from osteoporotic vertebrae, infiltrated with acrylic cement at a constant flow rate, and the pressure drop across the cores during the infiltration was measured. The viscosity dependence of the permeability was determined based on published experimental data. The theoretical model for the permeability as a function of bone porosity and time was then fit to the testing data. Our findings suggest that the intertrabecular bone permeability depends strongly on time. For instance, the initial permeability (60.89 mm(4)/N*s) reduced to approximately 63% of its original value within 18 seconds. This study is the first to analyze cement flow through osteoporotic bone. The theoretical and experimental models provided in this paper are generic. Thus, they can be used to systematically study and optimize the infiltration process for clinical practice. (C) 2003 IPEM. Published by Elsevier Science Ltd. All rights reserved.