L3T4-positive T lymphoblasts are responsible for transfer of immunity to Trichinella spiralis in mice.
L3T4-positive T lymphoblasts are responsible for transfer of immunity to Trichinella spiralis in mice.
复制标题
L3T4 阳性 T 淋巴细胞负责小鼠体内对旋毛虫的免疫转移。
作者：
R. Grencis;J. Riedlinger;D. Wakelin
淋巴细胞亚群参与介导免疫肠道线虫旋毛虫在体内的特点已经检查过继转移结合准确的细胞分选和细胞耗竭技术。使用FACS分选和单位重力下的速度沉降对细胞亚群进行阳性选择，证实快速分裂的T母细胞是介导蠕虫从肠道排出的主要群体。此外，细胞耗竭研究表明，涉及的T细胞亚群是L3 T4 + ve Lyt 2-ve表型。这种表型提示II类MHC在T.在体内通过T细胞表达螺旋体抗原。这些T细胞在对T细胞免疫中所起的作用。从淋巴因子释放的角度讨论了螺旋体。
The characteristics of lymphocyte subpopulations involved in mediating immunity to the intestinal nematode Trichinella spiralis in vivo have been examined using adoptive transfer in conjunction with accurate cell-sorting and cell-depletion techniques. Positive selection of cell subsets, using FACS sorting and velocity sedimentation at unit gravity, confirm that rapidly dividing T blasts are the major population that mediates expulsion of the worm from the gut. Furthermore, cell-depletion studies demonstrated that the T-cell subset involved is of the L3T4 + ve Lyt 2-ve phenotype. This phenotype suggests class II MHC restriction in recognition of T. spiralis antigens by T cells in vivo. The roles that such T cells play in immunity to T. spiralis are discussed in terms of lymphokine release.