The Frequency of Autoimmune N-Methyl-D-Aspartate Receptor Encephalitis Surpasses That of Individual Viral Etiologies in Young Individuals Enrolled in the California Encephalitis Project
The Frequency of Autoimmune N-Methyl-D-Aspartate Receptor Encephalitis Surpasses That of Individual Viral Etiologies in Young Individuals Enrolled in the California Encephalitis Project
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DOI：
10.1093/cid/cir1038
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发表时间：
2012-04-01
影响因子：
11.8
通讯作者：
Glaser, Carol A.
中科院分区：
文献类型：
--
作者：
Gable, Mary S.;Sheriff, Heather;Glaser, Carol A.
背景2007年，为研究脑炎流行病学而建立的加州脑炎项目（CEP）开始识别抗N-甲基-D-天冬氨酸受体（抗NMDAR）脑炎病例。CEP已确定越来越多的抗NMDAR脑炎病例，这种形式可与常见的病毒病因学作为致病因子相媲美。我们在此报告CEP经验中抗NMDAR和病毒病因引起的脑炎的相对频率和差异。将抗NMDAR脑炎患者的人口统计学、频率和临床数据与病毒性脑炎患者进行比较：肠道病毒、单纯疱疹病毒1型（HSV-1）、水痘-带状疱疹病毒（VZV）和西尼罗河病毒（WNV）。2007年9月至2011年2月期间向CEP提交的所有检查病例仅限于年龄为HSV-1、WNV或VZV频率4倍的个体，并且是我们队列中确定的主要实体。我们发现65%的抗NMDAR脑炎发生在老年人，
Background. In 2007, the California Encephalitis Project (CEP), which was established to study the epidemiology of encephalitis, began identifying cases of anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis. Increasing numbers of anti-NMDAR encephalitis cases have been identified at the CEP, and this form rivals commonly known viral etiologies as a causal agent. We report here the relative frequency and differences among encephalitides caused by anti-NMDAR and viral etiologies within the CEP experience.Methods. Demographic, frequency, and clinical data from patients with anti-NMDAR encephalitis are compared with those with viral encephalitic agents: enterovirus, herpes simplex virus type 1 (HSV-1), varicella-zoster virus (VZV), and West Nile virus (WNV). All examined cases presented to the CEP between September 2007 and February 2011 and are limited to individuals aged 4 times as frequently as HSV-1, WNV, or VZV and was the leading entity identified in our cohort. We found that 65% of anti-NMDAR encephalitis occurred in patients aged