How fast do we age? Exercise performance over time as a biomarker
How fast do we age? Exercise performance over time as a biomarker
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DOI：
10.1093/gerona/51a.5.m223
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发表时间：
1996-09-01
影响因子：
5.1
通讯作者：
Bortz, WM
中科院分区：
文献类型：
--
作者：
Bortz, WM;Bortz, WM
背景人类真实的时序功能变化率以前曾因无意中纳入来自患病或病态个体的数据而被掩盖。大师赛运动员满足了学习cohort的需要。从公认的跑步、划船和游泳项目认证机构收集按年龄划分的性能数据，并绘制从35岁起的下降百分比，并绘制按年龄划分的性能下降率。观察到的事件的衰变斜率的密切重合。这一比率为每年0.5%。我们认为，由于这些激烈的事件是由大多数主要的身体系统，从而由他们所有的速率限制，没有支持系统可以下降速度超过这个速度。不同运动项目的性能斜率彼此之间以及与其他功能（包括中枢生理测量VO2 max）的性能斜率的虚拟身份表明，每年0.5%可能是衰老过程的基本生物标志物。
Background. The rate of true chronologic functional change in humans has been previously obscured by inadvertent inclusion of data derived from sick or ill-conditioned individuals. The Masters athlete fulfills the need for a study cohort.Methods. Performance data by age were collected from recognized certifying organizations for running, rowing, and swimming events and plotted as percent decline from age 35, and a rate of decline of performance by age was plotted.Results. Close coincidence of the decay slopes of the events surveyed was observed. This rate is 0.5% per year. We argue that inasmuch as these strenuous events are subtended by most of the major body systems and are thereby rate-limited by them all, that no supporting system can decline faster than this rate.Conclusion. The virtual identity of the performance slopes of the different athletic events with one another and to that of other functions including that of a central physiologic measure, VO2 max, indicates that 0.5% per year may be a basic biomarker of the aging process.