Antibacterial activity of hydrolyzable tannins derived from medicinal plants against Helicobacter pylori
Antibacterial activity of hydrolyzable tannins derived from medicinal plants against Helicobacter pylori
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DOI：
10.1111/j.1348-0421.2004.tb03521.x
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发表时间：
2004-01-01
影响因子：
2.6
通讯作者：
Hirai, Y
中科院分区：
文献类型：
--
作者：
Funatogawa, K;Hayashi, S;Hirai, Y
幽门螺杆菌是胃十二指肠疾病的主要病原体。本研究从药用植物中分离得到36种多酚类化合物和4种萜类化合物，并研究了它们对H。pylori的体外研究。所有的水解单宁都表现出良好的抑菌活性。幽门。单体可水解单宁表现出特别强的活性。其他化合物表现出最小的抗菌活性，只有少数例外。Tellimagrandin I是一种单体可水解单宁，对H. pylori的体外研究。另一方面，水解单宁不影响来自人胃上皮的MKN-28细胞的活力。因此，水解单宁有可能作为新的和安全的治疗方案，对H。幽门感染此外，我们研究了可水解单宁对脂双层膜的影响。所有测试的可水解单宁表现出剂量依赖性的膜损伤活性。然而，其膜损伤活性是否直接有助于其抗菌作用仍有待阐明。
Helicobacter pylori is a major etiological agent in gastroduodenal disorders. In this study, we isolated 36 polyphenols and 4 terpenoids from medicinal plants, and investigated their antibacterial activity against H. pylori in vitro. All hydrolyzable tannins tested demonstrated promising antibacterial activity against H. pylori. Monomeric hydrolyzable tannins revealed especially strong activity. Other compounds demonstrated minimal antibacterial activity with a few exceptions. A monomeric hydrolyzable tannin, Tellimagrandin I demonstrated time- and dose-dependent bactericidal activity against H. pylori in vitro. On the other hand, hydrolyzable tannins did not affect the viability of MKN-28 cells derived from human gastric epithelium. Hydrolyzable tannins, therefore, have potential as new and safe therapeutic regimens against H. pylori infection. Furthermore, we investigated effects of hydrolyzable tannins on lipid bilayer membranes. All the hydrolyzable tannins tested demonstrated dose-dependent membrane-damaging activity. However, it remains to be elucidated whether their membrane-damaging activity directly contributes to their antibacterial action.