Neuronal identity control by terminal selectors in worms, flies, and chordates
Neuronal identity control by terminal selectors in worms, flies, and chordates
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DOI：
10.1016/j.conb.2018.12.006
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发表时间：
2019-06-01
影响因子：
5.7
通讯作者：
Kratsios, Paschalis
中科院分区：
文献类型：
--
作者：
Hobert, Oliver;Kratsios, Paschalis
有丝分裂后的神经元如何获得并维持其终末特性？对线虫秀丽隐杆线虫的基因突变分析揭示了控制神经元特性的常见分子程序。被称为终末选择器的神经元类型特异性转录因子组合作为主调控因子，通过直接调控神经元类型特异性效应基因来启动和维持终末特性程序。我们在此将提供近期研究的最新情况，这些研究巩固了蠕虫、果蝇和脊索动物中的终末选择器概念。我们还将描述秀丽隐杆线虫近期的研究工作如何扩展了终末选择器概念，以解释神经元亚型的多样化以及神经元特性的可塑性。
How do post-mitotic neurons acquire and maintain their terminal identity? Genetic mutant analysis in the nematode Caenorhabditis elegans has revealed common molecular programs that control neuronal identity. Neuron type-specific combinations of transcription factors, called terminal selectors, act as master regulatory factors to initiate and maintain terminal identity programs through direct regulation of neuron type-specific effector genes. We will provide here an update on recent studies that solidify the terminal selector concept in worms, flies and chordates. We will also describe how the terminal selector concept has been expanded by recent work in C. elegans to explain neuronal subtype diversification and plasticity of neuronal identity.