The role of brain-gut peptides in the control of sodium appetite.
The role of brain-gut peptides in the control of sodium appetite.
复制标题
脑肠肽在控制钠食欲中的作用。
DOI：
10.1111/j.1749-6632.1999.tb07891.x
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发表时间：
1999
影响因子：
5.2
通讯作者：
Power,JD
中科院分区：
文献类型：
--
作者：
Edwards,GL;Power,JD
摘要：摄入食物和液体会刺激胃肠道系统释放一些多肽。这些多肽被认为是神经递质/神经调节剂，作用于外周和中枢受体。许多研究表明，这些多肽是终止进餐的重要信号。最近的研究表明蛙皮素，一种与胃泌素释放肽有关的肽，可以抑制钠的食欲。我们研究了胆囊收缩素(CCK)在控制食欲中的作用。我们的研究表明，CCK在减少盐水摄入量方面是有效的。我们发现外源性的八肽CCK能抑制生理盐水的摄取。此外，给予胰酶抑制剂刺激内源性CCK的释放会抑制生理盐水的摄取。最后，腹腔注射CCK受体拮抗剂洛谷胺可增加生理盐水摄入量。这些观察扩大了胃肠肽在调节摄食行为中的潜在作用。
Abstract:Ingestion of food and fluid stimulates release of a number of peptides from the gastrointestinal system. These peptides are recognized to act as neurotransmitters/neuromodulators and act at both peripheral and central receptors. Many studies indicate that these peptides are important signals in terminating meals. Recent studies suggest that bombesin, a peptide related to gastrin‐releasing peptide, suppresses sodium appetite. We have investigated the role of cholecystokinin (CCK) in the control of sodium appetite. Our studies indicate that CCK is effective at reducing saline intake. We found that exogenous, intraperitoneal CCK octapeptide suppresses saline intake. Moreover, administration of trypsin inhibitor to stimulate endogenous CCK release resulted in suppression of saline intake. Finally, intraperitoneal administration of the CCK receptor antagonist lorglumide resulted in increased saline intake. These observations extend the potential role of gastrointestinal peptides in the modulation of ingestive behavior.