Relationship between stenting time and regeneration of neoesophageal submucosal tissue.
Relationship between stenting time and regeneration of neoesophageal submucosal tissue.
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DOI：
10.1097/00002480-199407000-00107
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发表时间：
1994-07-01
期刊：
影响因子：
--
通讯作者：
Shimizu, Y
中科院分区：
文献类型：
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作者：
Takimoto, Y;Teramachi, M;Shimizu, Y
作者研制了一种新型的人工食管，由内管硅胶管和外管非抗原性胶原管组成。这种人工食管的新特点是假体的主要部分被宿主组织取代。在之前的研究中，作者发现，当置换部分植入支架超过4周时，人工食管未发生狭窄。据认为，这种狭窄主要是由粘膜下组织再生不良引起的，而不是由上皮再形成的程度引起的。在本研究中，发现在支架在3周内脱落的病例中，在新食管上皮下观察到纤维组织。在这种情况下，既没有肌肉层，也没有粘膜下腺体再生下新食管上皮更换后。然而，在术后超过4周支架脱落的病例中，新生食管被多层鳞状上皮覆盖，并具有正常的食管腺体和肌肉层。因此，可以得出结论，当人工食管替代的部分植入支架至少4周时，肌肉组织和食管腺能够在新食管中再生。
The authors developed a new type of artificial esophagus consisting of an inner silicone tube and an outer non antigenic collagen tube. The novel feature of this artificial esophagus is that the main part of the prosthesis is replaced by host tissue. In a previous study, the authors found that no stenosis of the artificial esophagus developed when the replacement part was stented for more than 4 weeks. It was considered that this stenosis was caused mainly by poor regeneration of submucosal tissue, rather than by the grade of reepithelialization. In this study, it was found that, in cases in which the stent dropped out within 3 weeks, fibrous tissue was noted beneath the neoesophageal epithelium. In such cases, neither muscle layers nor submucosal glands regenerated beneath the neoesophageal epithelium after replacement. However, in cases in which the stent dropped out more than 4 weeks after surgery, the neoesophagus was covered with a polylayer of squamous epithelium and had normal esophageal glands and a muscle layer. Therefore, it was concluded that muscle tissue and esophageal glands were able to regrow in the neoesophagus when the portion replaced by the artificial esophagus was stented for at least 4 weeks.