Heparan sulphate identified on human erythrocytes:: a Plasmodium falciparum receptor
Heparan sulphate identified on human erythrocytes:: a Plasmodium falciparum receptor
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DOI：
10.1042/bj20040762
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发表时间：
2004-08-01
影响因子：
4.1
通讯作者：
Spillmann, D
中科院分区：
文献类型：
--
作者：
Vogt, AM;Winter, G;Spillmann, D
迄今为止，尚未在人类红细胞（RBC、红细胞）中发现 HS（硫酸乙酰肝素）。然而，疟疾寄生虫（恶性疟原虫）感染的红细胞通过 HS 样受体粘附到未感染的红细胞上。在本文中，我们证明人类红细胞携带抗 HS 抗体的表位。从红细胞膜中分离出的聚糖对 HS 特异性降解产生反应，并粘附到 HS 结合疟疾抗原上。此外，还鉴定出了 HS 核心蛋白。这表明 HS 存在于人类红细胞上。
HS (heparan sulphate) has hitherto not been found on human red blood cells (RBCs, erythrocytes). However, malarial-parasite (Plasmodium falciparum)-infected RBCs adhere to uninfected RBCs via HS-like receptors. In the present paper we demonstrate that human RBCs carry epitopes for an anti-HS antibody. Glycans isolated from RBC membranes reacted to HS-specific degradations and adhered to an HS-binding malaria antigen. Additionally, an HS core protein was identified. This suggests that HS is present on human RBCs.