Effect of weight reduction on liver histology and biochemistry in patients with chronic hepatitis C
Effect of weight reduction on liver histology and biochemistry in patients with chronic hepatitis C
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DOI：
10.1136/gut.51.1.89
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发表时间：
2002-07-01
期刊：
影响因子：
24.5
通讯作者：
Powell, EE
中科院分区：
文献类型：
--
作者：
Hickman, IJ;Clouston, AD;Powell, EE
背景：超过50%的慢性丙型肝炎患者会发生脂肪变性，并与肝纤维化增加有关。在这些患者中，脂肪变性的发病机制似乎与非酒精性脂肪性肝病患者类似-即与内脏肥胖和肥胖有关。方法：对19例脂肪肝和慢性丙型肝炎患者进行为期3个月的减肥计划对肝脏生化和代谢参数的影响，并在干预前和干预后3-6个月对10名患者进行配对肝活检，以确定减肥对肝脏组织学的影响。结果：体重平均减轻5.9(3.2)kg，腰围平均减少9.0(5.0)cm。在19名患者中，有16名患者的血清丙氨酸氨基转移酶水平随着体重的减轻而逐渐下降。平均空腹胰岛素从16(7)降至11(4)mmol/L(p
Background: Steatosis occurs in more than 50% of patients with chronic hepatitis C and is associated with increased hepatic fibrosis. In many of these patients the pathogenesis of steatosis appears to be the some as for patients with non-alcoholic fatty liver disease-that is, related to visceral adiposity and obesity.Methods: The effect of a three month weight reduction programme on liver biochemistry and metabolic parameters was examined in 19 subjects with steatosis and chronic hepatitis C. Paired liver biopsies were performed in 10 subjects, prior to and 3-6 months following the intervention, to determine the effect of weight loss on liver histology.Results: There was a mean weight loss of 5.9 (3.2) kg and a mean reduction in waist circumference of 9.0 (5.0) cm. In 16 of the 19 patients, serum alanine aminotransferase levels fell progressively with weight loss. Mean fasting insulin fell from 16 (7) to 11 (4) mmol/l (p