Lack of periconceptional vitamins or supplements that contain folic acid and diabetes mellitus-associated birth defects
Lack of periconceptional vitamins or supplements that contain folic acid and diabetes mellitus-associated birth defects
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DOI：
10.1016/j.ajog.2011.12.018
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发表时间：
2012-03-01
影响因子：
9.8
通讯作者：
Reece, E. Albert
中科院分区：
文献类型：
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作者：
Correa, Adolfo;Gilboa, Suzanne M.;Reece, E. Albert
目的：本研究的目的是调查与糖尿病和缺乏围孕期维生素或含叶酸补充剂相关的出生缺陷风险。 研究设计：国家出生缺陷预防研究（1997-2004）是一项多中心、基于人群的出生缺陷病例对照研究（14,721 例和 5437 名对照婴儿）。病例分为 18 种心脏缺陷和 26 种非心脏出生缺陷。我们估计了既往糖尿病和围孕期缺乏使用含叶酸的维生素或补充剂的独立影响和联合影响的比值比。结果：比值比的模式表明，与围孕期不使用含叶酸的维生素或补充剂相比，与存在糖尿病相关的缺陷的风险增加。结论：围孕期缺乏使用含叶酸的维生素或补充剂的情况下，与糖尿病相关的缺陷风险增加。叶酸可能与糖尿病引起的出生缺陷风险过高有关。
OBJECTIVE: The purpose of this study was to examine the risk of birth defects in relation to diabetes mellitus and the lack of use of periconceptional vitamins or supplements that contain folic acid.STUDY DESIGN: The National Birth Defects Prevention Study (1997-2004) is a multicenter, population-based case-control study of birth defects (14,721 cases and 5437 control infants). Cases were categorized into 18 types of heart defects and 26 noncardiac birth defects. We estimated odds ratios for independent and joint effects of preexisting diabetes mellitus and a lack of periconceptional use of vitamins or supplements that contain folic acid.RESULTS: The pattern of odds ratios suggested an increased risk of defects that are associated with diabetes mellitus in the absence vs the presence of the periconceptional use of vitamins or supplements that contain folic acid.CONCLUSION: The lack of periconceptional use of vitamins or supplements that contain folic acid may be associated with an excess risk for birth defects due to diabetes mellitus.