IGF-I receptor is required for the anabolic actions of parathyroid hormone on bone
IGF-I receptor is required for the anabolic actions of parathyroid hormone on bone
复制标题
DOI：
10.1359/jbmr.070517
复制
发表时间：
2007-09-01
影响因子：
6.2
通讯作者：
Bikle, Daniel D.
中科院分区：
文献类型：
--
作者：
Wang, Yongmei;Nishida, Shigeki;Bikle, Daniel D.
我们发现，IGF-IR-无效突变在成熟的成骨细胞导致骨少，减少骨膜骨形成和受损的PTH对骨祖细胞增殖和分化的刺激作用。
We showed that the IGF-IR-null mutation in mature osteoblasts leads to less bone and decreased periosteal bone formation and impaired the stimulatory effects of PTH on osteoprogenitor cell proliferation and differentiation.