The diagnosis and treatment of hepatocellular carcinoma
The diagnosis and treatment of hepatocellular carcinoma
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DOI：
10.1053/j.semdp.2016.12.011
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发表时间：
2017-03-01
影响因子：
2.3
通讯作者：
Ghabril, Marwan
中科院分区：
文献类型：
--
作者：
Hartke, Justin;Johnson, Matthew;Ghabril, Marwan
肝细胞癌是世界范围内的主要癌症。其发病率呈上升趋势，且与晚期肝病密切相关。肝硬化是这种恶性肿瘤的最大危险因素，也是筛查和监测的主要指征。肝细胞癌的诊断可以经常和独特地基于特征性的多相对比的横截面成像，而不是严格需要组织取样。尽管医学、局部区域和手术治疗取得了进展，但肝细胞癌仍然是全球癌症相关死亡的最常见原因之一。在这篇综述中，目前的方法来管理肝细胞癌进行了讨论，其中包括肿瘤和病人的因素。突出强调了手术（切除，肝移植），局部（消融和栓塞治疗）和药物治疗的突出考虑因素。(C)2017爱思唯尔公司All rights reserved.
Hepatocellular carcinoma is a leading cancer worldwide. Its incidence is increasing, and is closely related to advanced liver disease. Cirrhosis represents the greatest risk factor for this malignancy, and is the main indication for screening and surveillance. The diagnosis of hepatocellular carcinoma can frequently, and uniquely, be made on characteristic multiphase contrast based cross-sectional imaging rather than strict need for tissue sampling. Despite advances in medical, locoregional and surgical therapies, hepatocellular carcinoma remains one of the most common causes of cancer-related death globally. In this review, current approaches to management of hepatocellular carcinoma are discussed, which incorporate both tumor and patient factors. The salient considerations in surgical (resection, liver transplantation), locoregional (ablation and embolic therapies) and medical therapies are highlighted. (C) 2017 Elsevier Inc. All rights reserved.