mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant
mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant
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DOI：
10.1101/2021.12.14.21267755
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发表时间：
2022-02-03
期刊：
影响因子：
64.5
通讯作者：
Balazs, Alejandro B.
中科院分区：
文献类型：
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作者：
Garcia-Beltran, Wilfredo F.;St Denis, Kerri J.;Balazs, Alejandro B.
最近的监测显示，SARS-CoV-2 Omicron变体(BA.1/B.1.1.529)的出现，在作为中和抗体目标的Spike蛋白中含有多达36个突变。考虑到其逃避疫苗诱导的体液免疫的潜力，我们检测了88份mRNA1273、111份BNT162b和40份Ad26.COV2.S疫苗接受者的血清对野生型、Delta和Omicron SARS-CoV-2伪病毒的中和效力。我们纳入了最近收到主要系列的个人(
Recent surveillance has revealed the emergence of the SARS-CoV-2 Omicron variant (BA.1/B.1.1.529) harboring up to 36 mutations in spike protein, the target of neutralizing antibodies. Given its potential to escape vaccine-induced humoral immunity, we measured the neutralization potency of sera from 88 mRNA-1273, 111 BNT162b, and 40 Ad26.COV2.S vaccine recipients against wild-type, Delta, and Omicron SARS-CoV-2 pseudoviruses. We included individuals that received their primary series recently (