Studies on the constituents of bocconia cordata. IV. Transformation of sanguinarine into bocconine
Studies on the constituents of bocconia cordata. IV. Transformation of sanguinarine into bocconine
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DOI：
10.1002/jhet.5570280806
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发表时间：
1991-12
影响因子：
2.4
通讯作者：
Y. Konda;M. Urano;Y. Harigaya;M. Onda
中科院分区：
文献类型：
--
作者：
Y. Konda;M. Urano;Y. Harigaya;M. Onda
用等摩尔的硝酸钾和硫酸硝化乙氧基血根碱，然后用氢氧化钠和甲醇处理，得到10-硝基甲氧基血根碱。10-硝基甲氧基山竹碱经氢化、重氮化、甲醇分解等反应生成博可宁。
Nitration of ethoxysanguinarine with equimolar potassium nitrate and sulfuric acid, followed by treatment with sodium hydroxide and methanol, gives 10-nitromethoxysanguinarine. Successive hydrogenation, diazotization and methanolysis convert 10-nitromethoxysanguinarine into bocconine.