Plasma Transthyretin as a Biomarker of Lean Body Mass and Catabolic States.
Plasma Transthyretin as a Biomarker of Lean Body Mass and Catabolic States.
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DOI：
10.3945/an.115.008508
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发表时间：
2015-09
期刊：
影响因子：
--
通讯作者：
Bernstein LH
中科院分区：
文献类型：
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作者：
Ingenbleek Y;Bernstein LH
血浆甲状腺素运载蛋白（TTR）是一种由肝脏分泌的血浆蛋白，与视黄醇结合蛋白4（RBP 4）及其视黄醇配体结合循环。TTR是唯一的血浆蛋白，揭示了从出生到老年的进化模式，这些模式与瘦体重（LBM）的进化模式密切重叠，因此可以作为LBM的最佳替代分析物。能量-蛋白质平衡的任何改变都会损害LBM储备的增加，并导致TTR产生的早期抑制。在急性炎症状态下，细胞因子诱导含氮catalysts的尿渗漏，耗尽LBM储存，并导致TTR和RBP 4浓度的突然降低。因此，甲状腺素和视黄醇配体以游离形式释放，形成第二条前线，加强主要由细胞因子引发的前线。因此，营养不良和炎症通过使用不同且不相关的生理途径来控制TTR和RBP 4的分泌，但它们共同作用以下调LBM储存。生物标志物复合物在任何时候整合这些相反的机制，从而构成了一个理想的合适的工具，以确定剩余的LBM资源仍然可用于代谢反应，因此预测最交织的疾病状况的结果。
Plasma transthyretin (TTR) is a plasma protein secreted by the liver that circulates bound to retinol-binding protein 4 (RBP4) and its retinol ligand. TTR is the sole plasma protein that reveals from birth to old age evolutionary patterns that are closely superimposable to those of lean body mass (LBM) and thus works as the best surrogate analyte of LBM. Any alteration in energy-to-protein balance impairs the accretion of LBM reserves and causes early depression of TTR production. In acute inflammatory states, cytokines induce urinary leakage of nitrogenous catabolites, deplete LBM stores, and cause an abrupt decrease in TTR and RBP4 concentrations. As a result, thyroxine and retinol ligands are released in free form, creating a second frontline that strengthens that primarily initiated by cytokines. Malnutrition and inflammation thus keep in check TTR and RBP4 secretion by using distinct and unrelated physiologic pathways, but they operate in concert to downregulate LBM stores. The biomarker complex integrates these opposite mechanisms at any time and thereby constitutes an ideally suited tool to determine residual LBM resources still available for metabolic responses, hence predicting outcomes of the most interwoven disease conditions.