STUDIES OF THE COAGULATION SYSTEM IN ARENAVIRAL HEMORRHAGIC-FEVER - EXPERIMENTAL-INFECTION OF STRAIN 13 GUINEA-PIGS WITH PICHINDE VIRUS
STUDIES OF THE COAGULATION SYSTEM IN ARENAVIRAL HEMORRHAGIC-FEVER - EXPERIMENTAL-INFECTION OF STRAIN 13 GUINEA-PIGS WITH PICHINDE VIRUS
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DOI：
10.4269/ajtmh.1987.36.416
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发表时间：
1987-03-01
影响因子：
3.3
通讯作者：
SMITH, JI
中科院分区：
文献类型：
--
作者：
COSGRIFF, TM;JAHRLING, PB;SMITH, JI
显著的凝血异常与皮钦德病毒（一种与人类强毒病原体朱宁、马丘波和拉沙病毒相关的沙粒病毒）实验性感染13号豚鼠株有关。感染动物出现多种凝血因子活性降低、抗凝血酶III水平降低、纤维蛋白-纤维蛋白原降解产物水平升高、血小板功能受损和血小板减少症。对凝血抑制剂的检测显示了与因子缺乏一致的模式。尸检时未发现血栓。高纤维蛋白原-纤维蛋白原降解产物水平和抗凝血酶III水平降低的结果，与多种凝血因子活性降低和血小板减少症相关，表明血管内凝血是该实验性感染的一个特征。血小板功能异常的证明也很重要，因为这可能导致止血缺陷，尽管中度血小板减少症通常发生在沙粒病毒病中。
Significant coagulation abnormalities were associated with experimental infection of strain 13 guinea pigs with Pichinde virus, an arenavirus related to the virulent human pathogens Junin, Machupo, and Lassa viruses. Infected animals developed decreased activity of multiple coagulation factors, decreased antithrombin III levels, high levels of fibrin-fibrinogen degradation products, impaired platelet function, and thrombocytopenia. Testing for the presence of a coagulation inhibitor revealed a pattern consistent with factor deficiency. Fibrin thrombi were not found at necropsy. The findings of high fibrin-fibrinogen degradation product levels and decreased antithrombin III levels, in association with decreased activity of multiple coagulation factors and thrombocytopenia, suggest that intravascular coagulation is a feature of this experimental infection. The demonstration of abnormal platelet function is also significant, as this could contribute to defective hemostasis despite the moderate thrombocytopenia which usually occurs in arenaviral disease.