Cortisol and ACTH responses to psychosocial stress are modulated by corticosteroid binding globulin levels
Cortisol and ACTH responses to psychosocial stress are modulated by corticosteroid binding globulin levels
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DOI：
10.1016/j.psyneuen.2007.08.007
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发表时间：
2007-09-01
影响因子：
3.7
通讯作者：
Wuest, S.
中科院分区：
文献类型：
--
作者：
Kumsta, R.;Entringer, S.;Wuest, S.
下丘脑-垂体-肾上腺（HPA）轴至关重要。对生理和心理压力的反应。皮质醇，分泌后激活HPA轴影响整个生物体的生理系统。对皮质醇的反应受到许多因素的影响和修改，包括皮质类固醇结合球蛋白（CBG）水平。循环皮质醇的主要部分与CBG结合，只有未结合部分被认为具有生物活性。本研究的目的是研究CBG水平对心理社会应激后激素反应的调节作用，女性使用口服避孕药（n = 115）和无药物治疗的男性（n = 93）。在女性中，CBG水平与ACTH和唾液皮质醇呈负相关，与总皮质醇呈正相关。在TSST之后的水平。在男性中，TSST后CBG和ACTH和总皮质醇水平之间观察到正相关。CBG是HPA轴反应模式的一个重要调节因素，因此，CBG水平必须考虑作为ACTH和皮质醇对心理社会和药理学刺激的潜在修饰剂，调查长期品尝OC摄入对女性神经内分泌应激调节的后果可能是必要的。(C)2007爱思唯尔有限公司保留所有权利。
The hypothalamus-pituitary-adrenal (HPA) axis is vital. for an organisms' response to physiological and psychological stress. Cortisol, secreted upon activation of the HPA axis impacts on physiological systems throughout the organism. Responses to cortisol are influenced and modified by a number of factors, including corticosteroid binding globulin (CBG) levels. A major part of circulating cortisol is bound to CBG and only the unbound fraction is thought to be biologically active. The aim of the present study was to examine the modulating effect of CBG levels on hormonal responses following psychosocial stress in women using oral contraceptives (n = 115) and in medication-free men (n = 93). In women, CBG levels were negatively associated with ACTH and salivary cortisol and positively with total cortisol. levels following the TSST. In men, positive associations were observed between CBG and ACTH and total cortisol levels following the TSST. CBG is an important regulatory element of HPA axis response patterns; therefore, CBG levels have to be taken into account as a potential modifier of ACTH and cortisol responses to psychosocial and pharmacological stimulation.Investigations of the consequences of long-tasting OC intake on the neuroendocrine stress regulation in women might be warranted. (C) 2007 Elsevier Ltd. All rights reserved.