Interactive Effect of Cigarette Smoking With Human 8-Oxoguanine DNA N-Glycosylase 1 (hOGG1) Polymorphisms on the Risk of Lung Cancer: A Case-Control Study in Taiwan
Interactive Effect of Cigarette Smoking With Human 8-Oxoguanine DNA N-Glycosylase 1 (hOGG1) Polymorphisms on the Risk of Lung Cancer: A Case-Control Study in Taiwan
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DOI：
10.1093/aje/kwp019
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发表时间：
2009-09-15
影响因子：
5
通讯作者：
Hsiung, Chao A.
中科院分区：
文献类型：
--
作者：
Chang, Chin-Hao;Hsiao, Chin-Fu;Hsiung, Chao A.
人8-氧代鸟嘌呤DNA N-糖基化酶1（hOGG 1）在烟草致癌物诱导的DNA氧化损伤修复中起重要作用。在这项病例对照研究中，作者研究了hOGG 1基因多态性和吸烟对台湾肺癌风险的交互作用。2002-2004年期间，台湾6个医学中心共招募了1，096例病例和1，007例对照。使用MassARRAY系统（SEQUENOM，Inc.，圣地亚哥，加州）。采用结构式问卷进行个人访谈，获得吸烟史。使用逻辑回归分析来估计多变量调整后的比值比和95%置信区间。Cys/Cys基因型与Ser/Ser基因型的人患肺癌的几率为1.11（95%置信区间（CI）：0.74，1.65）从不吸烟者，1.45（95% CI：0.74，2.83）中度吸烟者，3.52（95% CI：1.54，8.06）重度吸烟者。logistic模型中相互作用的P值为0.01。重度吸烟者中与Cys/Cys基因型相关的风险增加对于各种组织学类型的肺癌（包括腺癌、鳞状细胞癌和小细胞癌）仍然具有统计学显著性。作者得出结论，吸烟状态对hOGG 1基因型与肺癌风险之间的关联有明显的修饰作用。
Human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) plays an important role in repairing oxidative DNA damage induced by tobacco carcinogens. In this case-control study, the authors examined the interactive effect of hOGG1 gene polymorphisms and cigarette smoking on the risk of lung cancer in Taiwan. A total of 1,096 cases and 1,007 controls were enrolled from 6 medical centers in Taiwan during 2002-2004. hOGG1 Ser326Cys genetic polymorphisms were determined using the MassARRAY system (SEQUENOM, Inc., San Diego, California). Tobacco smoking history was obtained through personal interview according to a structured questionnaire. Logistic regression analysis was used to estimate multivariate-adjusted odds ratios and 95% confidence intervals. The odds of developing lung cancer for persons with the Cys/Cys genotype versus the Ser/Ser genotype were 1.11 (95% confidence interval (CI): 0.74, 1.65) for never smokers, 1.45 (95% CI: 0.74, 2.83) for moderate smokers, and 3.52 (95% CI: 1.54, 8.06) for heavy smokers. The P value for interaction in the logistic model was 0.01. The increased risk associated with the Cys/Cys genotype among heavy smokers remained statistically significant for various histologic types of lung cancer, including adenocarcinoma, squamous cell carcinoma, and small cell carcinoma. The authors conclude that there was a noticeable modifying effect on the association between hOGG1 genotype and lung cancer risk by cigarette smoking status.