A study of properties of "micelle-enhanced" polyelectrolyte capsules: Structure, encapsulation and in vitro release.
A study of properties of "micelle-enhanced" polyelectrolyte capsules: Structure, encapsulation and in vitro release.
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DOI：
10.1016/j.actbio.2009.01.045
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发表时间：
2009-07
影响因子：
9.7
通讯作者：
Xiaodong Li;Tian Lu;Jianxiang Zhang;Jiajie Xu;Qiaoling Hu;Shi-fang Zhao;Jia-cong Shen
中科院分区：
文献类型：
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作者：
Xiaodong Li;Tian Lu;Jianxiang Zhang;Jiajie Xu;Qiaoling Hu;Shi-fang Zhao;Jia-cong Shen
“胶束增强”聚电解质胶囊通过一层一层的技术，模板化的混合碳酸钙颗粒内置聚合物胶束基于聚苯乙烯-b-聚丙烯酸。由于聚电解质胶囊内部存在大量带负电荷的胶束，这些胶束从模板中被释放出来，从而重建了胶囊壁，并具有不同于传统聚电解质胶囊的性能。这种胶囊可以选择性地捕获带正电的水溶性物质。带正电物质的包封效率取决于其分子量或大小。对于一些带正电的化合物，如罗丹明B和溶菌酶，胶囊中的浓度比孵育液中的浓度高几个数量级。体外释放实验表明，所包被的化合物有一定程度的持续释放。所有这些结果表明，这些胶囊可能用作一些水溶性化合物的新型递送系统。
“Micelle-enhanced” polyelectrolyte capsules were fabricated via a layer-by-layer technique, templated on hybrid calcium carbonate particles with built-in polymeric micelles based on polystyrene-b-poly(acrylic acid). Due to the presence of a large number of negatively charged micelles inside the polyelectrolyte capsule, which were liberated from templates, the capsule wall was reconstructed and had properties different to those of conventional polyelectrolyte capsules. This type of capsule could selectively entrap positively charged water-soluble substances. The encapsulation efficiency of positively charged substances was dependent on their molecular weight or size. For some positively charged compounds, such as rhodamine B and lysozyme, the concentration in the capsules was orders of magnitude higher than that in the incubation solution. In addition, in vitro release study suggested that the encapsulated compounds could be released through a sustained manner to a certain degree. All these results point to the fact that these capsules might be used as novel delivery systems for some water-soluble compounds.