Comparative rates of androgen production and metabolism in Caucasian and Chinese subjects.
Comparative rates of androgen production and metabolism in Caucasian and Chinese subjects.
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DOI：
10.1210/jcem.83.6.4898
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发表时间：
1998-06
期刊：
影响因子：
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通讯作者：
S. Santner;Bradley Albertson;Gui-yuan Zhang;Guangkuo Zhang;Michael Santulli;Christina Wang;L. M. Deme
中科院分区：
文献类型：
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作者：
S. Santner;Bradley Albertson;Gui-yuan Zhang;Guangkuo Zhang;Michael Santulli;Christina Wang;L. M. Deme
临床上明显的前列腺癌发生在生活在西方国家的高加索人比在远东的中国人更常见。先前的研究表明，中国男性面部和体毛减少，血浆3 α-雄甾烷葡糖苷酸和雄甾酮葡糖苷酸水平低于白人男性。基于这些发现，研究人员推测中国男性可能降低了5 α-还原酶活性，导致前列腺组织双氢睾酮水平降低和临床上明显的前列腺癌。另一种假设表明，3 α-雄甾烷葡糖苷酸和雄甾酮葡糖苷酸水平降低可能反映了遗传或环境因素导致的雄激素类固醇前体的产生减少。本研究探讨了5 α-还原酶活性，雄激素类固醇前体，以及遗传和环境/饮食因素的影响，在中国和高加索男性群体。我们发现生活在中国北京的中国受试者和生活在宾夕法尼亚州的高加索人之间的5 β：5 α还原尿类固醇（5 α还原酶活性的标志物）的比率没有显著差异。为了提高检测的灵敏度，我们使用同位素动力学方法直接测量5 α-还原酶活性，并发现组间睾酮转化为双氢睾酮的比率没有差异。然后，解决备择假设，我们发现，高加索受试者排泄显着更高水平的个人和总雄激素类固醇比他们的中国同行。为了区分遗传和环境/饮食因素是导致这些差异的原因，我们比较了生活在宾夕法尼亚州的中国男性和生活在中国北京的类似人群。我们检测到睾丸激素的产生率和总血浆睾酮和性激素结合水平的降低，但在北京中国人的睾丸激素MCR中没有，而不是那些生活在宾夕法尼亚州的人。比较宾夕法尼亚州的中国人与他们的白人同行，我们没有发现显着差异，总睾酮，游离和弱结合睾酮，性激素结合球蛋白水平，睾酮生产率。总之，这些研究表明，环境/饮食，而不是遗传因素，影响雄激素的生产和解释高加索人和中国男性之间的差异。
Clinically apparent prostate cancer occurs more commonly among Caucasians living in Western countries than in Chinese in the Far East. Prior studies demonstrated diminished facial and body hair and lower levels of plasma 3 alpha-androstanediol glucuronide and androsterone glucuronide in Chinese than in Caucasian men. Based upon these findings, investigators postulated that Chinese men could have diminished 5 alpha-reductase activity with a resultant decrease in prostate tissue dihydrotestosterone levels and clinically apparent prostate cancer. An alternative hypothesis suggests that decreased 3 alpha-androstanediol glucuronide and androsterone glucuronide levels might reflect reduced production of androgenic ketosteroid precursors as a result of genetic or environmental factors. The present study examined 5 alpha-reductase activity, androgenic ketosteroid precursors, and the influence of genetic and environmental/dietary factors in groups of Chinese and Caucasian men. We found no significant differences in the ratios of 5 beta-:5 alpha-reduced urinary steroids (a marker of 5 alpha-reductase activity) between Chinese subjects living in Beijing, China, and Caucasians living in Pennsylvania. To enhance the sensitivity of detection, we used an isotopic kinetic method to directly measure 5 alpha-reductase activity and found no difference in testosterone to dihydrotestosterone conversion ratios between groups. Then, addressing the alternative hypothesis, we found that the Caucasian subjects excreted significantly higher levels of individual and total androgenic ketosteroids than did their Chinese counterparts. To distinguish genetic from environmental/dietary factors as a cause of these differences, we compared Chinese men living in Pennsylvania and a similar group living in Beijing, China. We detected a reduction in testosterone production rates and total plasma testosterone and sex hormone-binding levels, but not in testosterone MCRs in Beijing Chinese as a opposed to those living in Pennsylvania. Comparing Pennsylvania Chinese with their Caucasian counterparts, we detected no significant differences in total testosterone, free and weakly bound testosterone, sex hormone-binding globulin levels, and testosterone production rates. Taken together, these studies suggest that environmental/dietary, but not genetic, factors influence androgen production and explain the differences between Caucasian and Chinese men.