Contrasting autonomic and hemodynamic effects of insulin in healthy elderly versus young subjects
Contrasting autonomic and hemodynamic effects of insulin in healthy elderly versus young subjects
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DOI：
10.1161/01.hyp.29.3.700
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发表时间：
1997-03-01
期刊：
影响因子：
8.3
通讯作者：
Anderson, EA
中科院分区：
文献类型：
--
作者：
Hausberg, M;Hoffman, RP;Anderson, EA
Acute increases in plasma insulin produce both sympathoexcitation and vasodilation in normal young adults. Aging is associated with insulin resistance and may alter the sympathetic or the vascular responses to insulin. Therefore, we assessed sympathetic and vascular responses to acute physiological increases in plasma insulin levers in IO healthy, normotensive elderly (65+/-2 years) and 12 normal young (27+/-1 years) subjects matched for body mass index (25+/-1 kg/m(2) in both groups). We measured muscle sympathetic nerve activity (microneurography), FBF (plethysmography), heart rate, and blood pressure and calculated forearm vascular resistance and insulin sensitivity (M value) during a 90-minute hyperinsulinemic/euglycemic clamp. M values were 4.3+/-0.4 mg . kg(-1). min(-1) in the elderly and 8.4+/-1.4 mg . kg(-1). min(-1) in the young subjects (P
