The family based association test method: strategies for studying general genotype-phenotype associations
The family based association test method: strategies for studying general genotype-phenotype associations
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DOI：
10.1038/sj.ejhg.5200625
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发表时间：
2001-04-01
影响因子：
5.2
通讯作者：
Laird, NM
中科院分区：
文献类型：
--
作者：
Horvath, S;Xu, X;Laird, NM
对于可能不完整的核心家庭，基于家庭的关联检验（FBAT）方法允许评估任何检验统计量，该检验统计量可以表示为后代基因型的任意函数与后代表型的任意函数之间的乘积（协方差）之和。我们推导出表达式需要计算的均值和方差的检验统计量的零假设下，没有联系。为了给使用FBAT方法提供一些指导，我们提出了三种简单的数据分析策略，用于不同的表型：二分法（情感状态），定量和删失（例如，发病年龄）。我们通过将其应用于NIMH阿尔茨海默病倡议的候选基因数据来说明这种方法。我们表明，RC-TDT是等效的FBAT方法的一个特殊情况。这一结果使我们能够将RC-TDT推广到显性、隐性和多等位基因标记编码。仿真结果将FBAT测试与RC-TDT和S-TDT进行了比较。FBAT软件免费提供。
With possibly incomplete nuclear families, the family based association test (FBAT) method allows one to evaluate any test statistic that can be expressed as the sum of products (covariance) between an arbitrary function of an offspring's genotype with an arbitrary function of the offspring's phenotype. We derive expressions needed to calculate the mean and variance of these test statistics under the null hypothesis of no linkage. To give some guidance on using the FBAT method, we present three simple data analysis strategies for different phenotypes: dichotomous (affection status), quantitative and censored (eg, the age of onset). We illustrate the approach by applying it to candidate gene data of the NIMH Alzheimer Disease Initiative. We show that the RC-TDT is equivalent to a special case of the FBAT method. This result allows us to generalise the RC-TDT to dominant, recessive and multi-allelic marker codings. Simulations compare the resulting FBAT tests to the RC-TDT and the S-TDT. The FBAT software is freely available.